tert-butyl[(1S,2E)-1-ethyl-5-trimethylsilylpent-2-en-4-ynyloxy]diphenylsilane | 870263-96-0

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: tert-butyl[(1S,2E)-1-ethyl-5-trimethylsilylpent-2-en-4-ynyloxy]diphenylsilane
• 英文别名: tert-butyl-diphenyl-[(E,3S)-7-trimethylsilylhept-4-en-6-yn-3-yl]oxysilane
• CAS: 870263-96-0
• 化学式: C₂₆H₃₆OSi₂
• 分子量: 420.742
• InChiKey: JGNJVPKITUWVHC-GGJDQLKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.78
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tert-butyl[(1S,2E)-1-ethyl-5-trimethylsilylpent-2-en-4-ynyloxy]diphenylsilane 在 4-二甲氨基吡啶 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (1S,2E,4Z,7E)-1-ethyl-8-{(1R,2S,3S,5S)-3-[(S)-6-oxotetrahydropyran-2-yl]-6-oxabicyclo[3.1.0]hex-2-yl}octa-2,4,7-trienyl acetate
  参考文献：
  名称：

  Synthesis and structural revision of marine eicosanoid agardhilactone

  摘要：

  Synthesis of the marine eicosanoid agardhilactone has been achieved. The relative and absolute configuration of agardhilactone was successfully determined. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.09.102
• 作为产物：
  描述：

  (S)-3-hydroxypent-1-yne 在 四(三苯基膦)钯 咪唑 、 正丙胺 、 copper(l) iodide 、 儿萘酚硼烷 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成 tert-butyl[(1S,2E)-1-ethyl-5-trimethylsilylpent-2-en-4-ynyloxy]diphenylsilane
  参考文献：
  名称：

  Synthesis and structural revision of marine eicosanoid agardhilactone

  摘要：

  Synthesis of the marine eicosanoid agardhilactone has been achieved. The relative and absolute configuration of agardhilactone was successfully determined. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.09.102

文献信息

• Synthesis of Marine Oxylipin Agardhilactone and Its Analogues: A Structural Revision
  作者：Hiroaki Miyaoka、Etsuko Kawashima、Yoshinori Hara、Ikuo Shinohara、Takao Kurokawa、Yasuji Yamada

  DOI：10.3987/com-08-s(f)97

  日期：——

  Synthesis of four analogues of the marine oxylipin agardhilactone was carried out. The relative configuration of agardhilactone was determined by comparison with agardhilactone acetate and four analogues. Furthermore, synthesis of agardhilactone was achieved. The absolute configuration of agardhilactone was successfully determined by this synthesis.