(2S)-6-methyl-2-(methylamino)heptanal

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2S)-6-methyl-2-(methylamino)heptanal
• 化学式: C₉H₁₉NO
• 分子量: 157.25
• InChiKey: KRQZSQYRCBYKCW-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PEPTIDOMIMETIC MACROCYCLES
  申请人：Aileron Therapeutics, Inc.

  公开号：EP3769776A1

  公开（公告）日：2021-01-27

  Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.

  本文提供了拟肽大环和使用这种大环治疗疾病的方法。
• [EN] PEPTIDOMIMETIC MACROCYCLES AND USE THEREOF IN REGULATING HIF1ALPHA<br/>[FR] MACROCYCLES PEPTIDOMIMÉTIQUES ET LEUR UTILISATION DANS LA RÉGULATION DE HIF1ALPHA
  申请人：AILERON THERAPEUTICS INC

  公开号：WO2014138429A2

  公开（公告）日：2014-09-12

  The present invention provides peptidomimetic macrocycles capable of regulating HIF1α and methods of using such macrocycles for the treatment of diseases.
• [EN] PEPTIDOMIMETIC MACROCYCLES WITH PTH ACTIVITY<br/>[FR] MACROCYCLES PEPTIDOMIMÉTIQUES À ACTIVITÉ PTH
  申请人：AILERON THERAPEUTICS INC

  公开号：WO2015157508A1

  公开（公告）日：2015-10-15

  The present invention provides peptidomimetic macrocycles capable of modulating parathyroid hormone levels and methods of using such macrocycles for the treatment of disease.
• [EN] PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF<br/>[FR] MACROCYCLES PEPTIDOMIMÉTIQUES ET FORMULATIONS DE CEUX-CI
  申请人：AILERON THERAPEUTICS INC

  公开号：WO2016049355A1

  公开（公告）日：2016-03-31

  Aqueous pharmaceutical formulations, for parenteral administration, comprising peptidomimetic macrocycle or a pharmaceutically acceptable salt thereof wherein the peptidomimetic macrocycle binds to MDM2 and/or MDMX proteins are disclosed. Also disclosed are methods of treating diseases and disorders using the aqueous pharmaceutical formulations disclosed herein.
• [EN] PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF<br/>[FR] MACROCYCLES PEPTIDOMIMÉTIQUES ET LEURS UTILISATIONS
  申请人：AILERON THERAPEUTICS INC

  公开号：WO2016049359A1

  公开（公告）日：2016-03-31

  Methods for treating solid tumor, determined to lack a p53 deactivation mutation, in a subject are provided. Also provided are peptidomimetic macrocycles for use in treatment of a solid tumor, determined to lack a p53 deactivation mutation, in a subject.