((2R,5R)-5-methyl-1,4-dioxan-2-yl)methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: ((2R,5R)-5-methyl-1,4-dioxan-2-yl)methanol
• 英文别名: [(2R,5R)-5-methyl-1,4-dioxan-2-yl]methanol
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: PWEKJQSIAQORIF-PHDIDXHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ((2R,5R)-5-methyl-1,4-dioxan-2-yl)methanol 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 ((2S,5R)-5-methyl-1,4-dioxan-2-yl)methyl methanesulfonate
  参考文献：
  名称：

  US2014/275082

  摘要：

  公开号：
• 作为产物：
  描述：

  (R)-2-((S)-oxiran-2-ylmethoxy)propan-1-ol 在 D(+)-10-樟脑磺酸 作用下， 以 二氯甲烷 为溶剂， 生成 ((2R,5R)-5-methyl-1,4-dioxan-2-yl)methanol
  参考文献：
  名称：

  US2014/275082

  摘要：

  公开号：

文献信息

• APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
  申请人：AbbVie Inc.

  公开号：US20150299197A1

  公开（公告）日：2015-10-22

  Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

  本文公开了一种抑制抗凋亡Bcl-2蛋白活性的化合物，包含这些化合物的组合物以及使用这些化合物治疗疾病的方法。
• Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
  申请人：AbbVie Inc.

  公开号：US10081628B2

  公开（公告）日：2018-09-25

  Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds. One embodiment of such compounds is 4-(4-[2-(4-chloro-2-fluorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-(3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide.

  本文公开了抑制抗凋亡 Bcl-2 蛋白活性的化合物、含有该化合物的组合物以及使用该化合物治疗疾病的方法。此类化合物的一个实施方案是 4-(4-[2-(4-氯-2-氟苯基)-4,4-二甲基环己-1-烯-1-基]甲基}哌嗪-1-基)-N-(3-硝基-4-[(四氢-2H-吡喃-4-基甲基)氨基]苯基}磺酰基)-2-(1H-吡咯并[2,3-b]吡啶-5-氧基)苯甲酰胺。
• Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation
  作者：Alessandro Piergentili、Wilma Quaglia、Fabio Del Bello、Mario Giannella、Maria Pigini、Elisabetta Barocelli、Simona Bertoni、Rosanna Matucci、Marta Nesi、Bruno Bruni

  DOI：10.1016/j.bmc.2009.10.027

  日期：2009.12.15

  Novel analogues of cis-N,N,N-trimethyl-(6-methyl-1,4-dioxan-2-yl)methanaminium iodide (2a) were synthesized by inserting methyl groups alternatively or simultaneously in positions 5 and 6 of the 1,4-dioxane nucleus in all combinations. Their biological profile was assessed by receptor binding assays at human muscarinic M-1-M-5 receptors stably expressed in CHO cells and by functional studies performed on classical isolated organ preparations, namely, rabbit electrically stimulated vas deferens, and guinea pig electrically stimulated left atrium, ileum, and lung strips. The results showed that the simultaneous presence of one methyl group in both positions 5 and 6 with a trans stereochemical relationship with each other (diastereomers 4 and 5) or the geminal dimethylation in position 6 (compound 8) favour the selective activation of M-3 receptors. Compounds 4, 5, and 8 might be valuable tools in the characterization of the M-3 receptor, as well as provide useful information for the design and development of novel selective M3 antagonists. (C) 2009 Elsevier Ltd. All rights reserved.
• US20140275082A1
  申请人：——

  公开号：US20140275082A1

  公开（公告）日：2014-09-18
• [EN] APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES<br/>[FR] AGENTS INDUISANT L'APOPTOSE POUR LE TRAITEMENT DU CANCER ET DE MALADIES IMMUNES ET AUTO-IMMUNES
  申请人：ABBVIE INC

  公开号：WO2014158528A1

  公开（公告）日：2014-10-02

  Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.