6-(α-Naphthylamino)-uracil | 21333-08-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-(α-Naphthylamino)-uracil
• 英文别名: 6-naphthalen-1-ylamino-1H-pyrimidine-2,4-dione；6-(1-naphthylamino)pyrimidine-2,4(1H,3H)-dione；6-(Naphthalen-1-ylamino)-1H-pyrimidine-2,4-dione
• CAS: 21333-08-4
• 化学式: C₁₄H₁₁N₃O₂
• 分子量: 253.26
• InChiKey: MBZFANWCRWUDIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.2
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Compounds inhibiting the aggregation of superoxide dismutase-1
  申请人：Lansbury Peter

  公开号：US20060194821A1

  公开（公告）日：2006-08-31

  The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.

  本发明涉及使用稳定SOD二聚体的化合物来抑制超氧化物歧化酶-1（SOD）聚集的速率的方法。该方法在进行肌萎缩侧索硬化的研究和治疗中非常有用。本发明还包括可用于识别稳定二聚体化合物和已经改性用于这些测定的SOD分子的测定方法。
• COMPOUNDS INHIBITING THE AGGREGATION OF SUPEROXIDE DISMUTASE-1
  申请人：The Brighamn and Women's Hospital, Inc.

  公开号：EP1853276A2

  公开（公告）日：2007-11-14
• [EN] COMPOUNDS INHIBITING THE AGGREGATION OF SUPEROXIDE DISMUTASE-1<br/>[FR] COMPOSES INHIBANT L'AGREGATION DE LA SUPEROXYDE DISMUTASE-1
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2006089221A2

  公开（公告）日：2006-08-24

  [EN] The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.
  [FR] L'invention concerne des méthodes permettant d'inhiber la vitesse à laquelle la superoxyde dismutase-1 (SOD) s'agrège à l'aide de composés qui stabilisent des dimères SOD. On utilise ces méthodes pour l'étude et la thérapie de la sclérose latérale amyotrophique. L'invention concerne également des dosages qui peuvent être utilisés pour identifier des composés qui stabilisent des dimères et des molécules SOD modifiés pour être utilisés dans lesdits dosages.