6-[3-(Dimethylamino)-2-methylphenyl]-7-phenylheptanoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 6-[3-(Dimethylamino)-2-methylphenyl]-7-phenylheptanoic acid
• 英文别名: 6-[3-(dimethylamino)-2-methylphenyl]-7-phenylheptanoic acid
• 化学式: C₂₂H₂₉NO₂
• 分子量: 339.5
• InChiKey: ZZARMRQTSMUETB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• ABUSE RESISTANT CAPSULE
  申请人：R.P. Scherer Technologies, LLC

  公开号：EP2968129A1

  公开（公告）日：2016-01-20
• [EN] ABUSE RESISTANT CAPSULE<br/>[FR] CAPSULE RÉSISTANTE AUX ABUS
  申请人：WENGNER SIMONE

  公开号：WO2014140231A1

  公开（公告）日：2014-09-18

  The present invention is directed to an immediate release and extended release capsule or capsule fill which mitigates the abuse of abuse-susceptible active pharmaceutical ingredients by direct intravenous injection. The fill comprises a parenteral abuse resistant liquid formulation which when mixed with water and heated, results in a turbid, viscous or bubbling mixture that is not injectable with a standard insulin syringe. The abuse-susceptible active pharmaceutical ingredient is selected from the group consisting of opiates, opioids, tranquillizers, stimulants and narcotics.
• [EN] CONTROLLED RELEASE FILL COMPOSITIONS AND CAPSULES CONTAINING SAME<br/>[FR] COMPOSITIONS DE REMPLISSAGE À LIBÉRATION CONTRÔLÉE ET CAPSULES LES CONTENANT
  申请人：[en]R.P. SCHERER TECHNOLOGIES, LLC

  公开号：WO2022081848A1

  公开（公告）日：2022-04-21

  A controlled release fill composition for use in soft or hard capsules, soft- or hard-shell capsules encapsulating controlled release fill compositions, a method of producing a softgel capsule with a controlled release fill composition encapsulated in the soft gel capsule shell. The controlled release fill composition includes an active pharmaceutical ingredient; polyethylene oxide having a number average molecule weight of from 0.05 M daltons to 15 M daltons; and at least one of water or a hydrophilic carrier having a number average molecule weight of from 200 daltons to 5000 daltons. Also, in the controlled release fill composition either the polyethylene oxide is present in an amount of at least 21.5 wt.%, based on a total weight of the controlled release fill composition, or the hydrophilic carrier is present in an amount up to 65 wt.%, based on a total weight of the controlled release fill composition.