(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;5,6-dimethoxy-2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;5,6-dimethoxy-2-methyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-indole
• 化学式: C43H51N11O7
• 分子量: 833.9
• InChiKey: AENWHTZFTALSHM-RSJBZBQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.13
• 重原子数：
  61
• 可旋转键数：
  15
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  251
• 氢给体数：
  6
• 氢受体数：
  16

文献信息

• METHOD OF PRODUCING AN IMMUNOLIGAN D/PAYLO AD CONJUGATE BY MEANS OF A SEQUENCE-SPECIFIC TRANSPEPTIDASE ENZYME
  申请人：NBE Therapeutics AG

  公开号：EP2968583A2

  公开（公告）日：2016-01-20
• [EN] METHOD OF PRODUCING AN IMMUNOLIGAND/PAYLOAD CONJUGATE<br/>[FR] PROCÉDÉ DE PRODUCTION D'UN CONJUGUÉ IMMUNOLIGAND/CHARGE
  申请人：NBE THERAPEUTICS LLC

  公开号：WO2014140317A2

  公开（公告）日：2014-09-18

  The present invention relates to a method of producing an immunoligand/payload conjugate, which method encompasses conjugating a payload to an immunoligand by means of a sequence-specific transpeptidase, or a catalytic domain thereof.