2-(5-Bromo-2-hydroxy-3-methoxyphenyl)-2-(3-chloro-4-fluoroanilino)acetonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(5-Bromo-2-hydroxy-3-methoxyphenyl)-2-(3-chloro-4-fluoroanilino)acetonitrile
• 英文别名: 2-(5-bromo-2-hydroxy-3-methoxyphenyl)-2-(3-chloro-4-fluoroanilino)acetonitrile
• 化学式: C₁₅H₁₁BrClFN₂O₂
• 分子量: 385.61
• InChiKey: DUARZYYOQFEKMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  65.3
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] AMINONITRILES AS KYNURENINE PATHWAY INHIBITORS<br/>[FR] AMINONITRILES EN TANT QU'INHIBITEURS DE LA VOIE DE LA KYNURÉNINE
  申请人：CURADEV PHARMA PVT LTD

  公开号：WO2014141110A2

  公开（公告）日：2014-09-18

  The present application provides novel kynurenine pathway inhibitors and pharmaceutically acceptable salts and prodrugs thereof. Also provided are methods for preparing these compounds. These compounds are useful in regulating the kynurenine pathway and the activity of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase by administering a therapeutically effective amount of one or more of the compounds of formula (I) to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the kynurenine pathway. A variety of conditions can be treated using these compounds and include diseases which are characterized by immunosuppression, abnormal cellular proliferation and/or inflammation. In one embodiment, the disease is cancer. In another embodiment, the disease is a viral infection. In a further embodiment, the disease is depression.