2-methylsulfanyl-benzothiazole-5-sulfonic acid | 25991-41-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-methylsulfanyl-benzothiazole-5-sulfonic acid
• 英文别名: 2-Methylmercapto-benzothiazol-5-sulfonsaeure；2-(Methylsulfanyl)-1,3-benzothiazole-5-sulfonic acid；2-methylsulfanyl-1,3-benzothiazole-5-sulfonic acid
• CAS: 25991-41-7
• 化学式: C₈H₇NO₃S₃
• 分子量: 261.346
• InChiKey: OGUZTNRCJXGCDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  129
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NUCLEIC ACID DETECTIONS AND METHODS OF THEIR USE
  申请人：Ying Laiqiang

  公开号：US20130137875A1

  公开（公告）日：2013-05-30

  The invention describes the preparation and use of fluorescent stains for nucleic acids derived from unsymmetrical cyanine dyes, dimmers, trimers, or tetramers. In particular, the invention describes unsymmetric cyanine dyes, dimmers, trimer and tetramers having a water soluble substituent. The dyes of the invention possess superior fluorescent properties when complexed with nucleic acids, and have utility in any application which requires detection of nucleic acids, such as detection of nucleic acids in solution, in gels, in blots, in microarrays, and in bacteria and cells, and for use in analysis of cell structure, membrane integrity, and function. The presence of the water soluble substituent results in improved water soluability and stability, resulting in improved detection of nucleic acids.

  该发明描述了从非对称青霉素染料、二聚体、三聚体或四聚体衍生的核酸荧光染料的制备和使用。具体而言，该发明描述了具有水溶性取代基的非对称青霉素染料、二聚体、三聚体和四聚体。该发明的染料在与核酸结合时具有优越的荧光特性，并可在任何需要检测核酸的应用中使用，例如在溶液中、凝胶中、斑点中、微阵列中、细菌和细胞中检测核酸，并用于细胞结构、膜完整性和功能的分析。水溶性取代基的存在导致改善了水溶性和稳定性，从而提高了对核酸的检测。
• Cyanine dye compounds
  申请人：Life Technologies Corporation

  公开号：EP2607431A1

  公开（公告）日：2013-06-26

  Cyanine dye compounds having a negatively charged substituent that are nucleic acid stains, particularly for fluorescent staining of DNA, including compounds having the formula (I) wherein W forms one or two fused 5- or 6-membered aromatic rings, α has a value of 0 or 1, n has a value of 0, or 1, X is O, S, or Se, and D is a pyridinium, or quinolinium moiety, provided that the compound has at least one negatively charged substituent.

  具有带负电荷取代基、可作为核酸染色剂，特别是用于 DNA 荧光染色的氰基染料化合物，包括具有式 (I) 的化合物 其中 W 形成一个或两个融合的 5 或 6 元芳香环，α 的值为 0 或 1，n 的值为 0 或 1，X 为 O、S 或 Se，D 为吡啶鎓或喹啉鎓分子，条件是该化合物具有至少一个带负电荷的取代基。
• Methods and apparatus for accelerated orthokeratology
  申请人：——

  公开号：US20010016731A1

  公开（公告）日：2001-08-23

  An accelerated method of orthokeratology includes the steps of softening of the cornea with a softening agent, applying a mold to reshape the cornea to a desired anterior curvature, and rapidly restabilizing or “fixing” the corneal tissues so that the cornea retains its new configuration. A chemical softening agent, such as glutaric anhydride is applied to the cornea to soften the cornea, after which a specially designed mold of predetermined curvature and configuration is applied to the cornea. Slight downward pressure is applied to the mold for a predetermined period of time to re-shape the cornea. The mold is maintained in position while a stabilizing agent, such as a UV light source, is positioned above the mold. The stabilizing agent, i.e. UV light, is applied to the cornea for a predetermined time, wherein the stabilizing agent immediately restabilizes the corneal tissue so that the cornea immediately retains its shape upon removal of the mold. The stabilization process can also be used for patients having already undergone traditional orthokeratology to eliminate the need to continue wearing a retainer to maintain the shape of the cornea.

  角膜矫形术的加速方法包括以下步骤：用软化剂软化角膜，使用模具将角膜重塑成所需的前弧度，并迅速重新稳定或 "固定 "角膜组织，使角膜保持新的形态。在角膜上涂抹化学软化剂（如戊二酸酐）以软化角膜，然后在角膜上涂抹专门设计的具有预定弧度和结构的模具。在预定时间内对模具施加轻微的向下压力，以重新塑形角膜。将稳定剂（如紫外线光源）置于模具上方时，模具将保持在原位。将稳定剂（即紫外线）照射到角膜上，持续预定的时间，其中稳定剂会立即重新稳定角膜组织，使角膜在移除模具后立即保持其形状。稳定过程也可用于已接受传统角膜矫形术的患者，使其无需继续佩戴保持器来保持角膜的形状。
• METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY
  申请人：Ista Pharmaceuticals, Inc.

  公开号：EP1051655A1

  公开（公告）日：2000-11-15
• EP1051655A4
  申请人：——

  公开号：EP1051655A4

  公开（公告）日：2003-03-19