N,N'-dimethyl-N'-[(E)-3-(2-methylhydrazinyl)prop-2-enyl]ethane-1,2-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-dimethyl-N'-[(E)-3-(2-methylhydrazinyl)prop-2-enyl]ethane-1,2-diamine
• 化学式: C₈H₂₀N₄
• 分子量: 172.27
• InChiKey: MSMWQQXSSFCBSF-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  39.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS D'ARGININE MÉTHYLTRANSFÉRASE ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2016044626A1

  公开（公告）日：2016-03-24

  Described herein are compounds of Formula (S-I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

  本文描述了式（S-I）的化合物，其药用盐以及药物组合物。本文描述的化合物对抑制精氨酸甲基转移酶活性有用。还描述了利用这些化合物治疗精氨酸甲基转移酶介导的疾病的方法。
• [EN] PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF<br/>[FR] DÉRIVÉS DE PYRAZOLE À TITRE D'INHIBITEURS DE PRMT1 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2014144659A1

  公开（公告）日：2014-09-18

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described.

  本文描述了化合物的结构式（I），其药用盐以及药物组合物。本文描述的化合物对抑制PRMT1活性有用。还描述了使用这些化合物治疗PRMT1介导的疾病的方法。
• [EN] PYRAZOLE DERIVATIVES ASPRMT1 INHIBITORS AND USES THEREOF<br/>[FR] DÉRIVÉS DE PYRAZOLE EN TANT QU'INHIBITEURS DE PRMT1 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2014153090A1

  公开（公告）日：2014-09-25

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMTl activity. Methods of using the compounds for treating PRMTl - mediated disorders are also described.
• [EN] PYRAZOLE DERIVATIVES AS ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ARGININE MÉTHYLTRANSFÉRASE ET UTILISATIONS DE CEUX-CI
  申请人：EPIZYME INC

  公开号：WO2014178954A1

  公开（公告）日：2014-11-06

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.Formula (I).
• [EN] PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF<br/>[FR] DÉRIVÉS DE PYRAZOLE EN TANT QU'INHIBITEURS DE PRMT1 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2014153172A1

  公开（公告）日：2014-09-25

  Described herein are compounds of Formula (I-a) and (I-b), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT1 activity. Methods of using the compounds for treating PRMT1-mediated disorders are also described.