2-amino-6-[(4-propan-2-ylanilino)methyl]-3H-pteridin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 2-amino-6-[(4-propan-2-ylanilino)methyl]-3H-pteridin-4-one
• 化学式: C₁₆H₁₈N₆O
• 分子量: 310.35
• InChiKey: UWWKCMAGGVAWNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer
  申请人：On Target Laboratories, LLC

  公开号：US10676487B2

  公开（公告）日：2020-06-09

  The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.

  本发明描述了可用于图像引导手术和光动力疗法的新型化合物。 特别是，这些化合物可通过使用针对病变组织上表达的受体的配体，然后通过受体介导的内吞作用，将化合物递送至病变组织（如癌症）后靶向作用于细胞核或线粒体，并对癌细胞和其他疾病提供有效的活性。 本文还介绍了使用这些配体的方法和组合物。
• Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
  申请人：Purdue Research Foundation

  公开号：US10881747B2

  公开（公告）日：2021-01-05

  The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

  本公开涉及可用作近红外荧光探针的化合物，其中化合物包括 i) 与靶受体蛋白结合的蝶酰配体；ii) 染料分子；iii) 由氨基酸或其衍生物组成的连接分子。本公开进一步描述了将这些化合物用于肿瘤靶向成像的方法和组合物。氨基酸连接基团的共轭增加了化合物的特异性和检测能力。考虑将其用于诊断成像的方法和组合物。
• Patient selection method for inflammation
  申请人：Purdue Research Foundation

  公开号：US11162937B2

  公开（公告）日：2021-11-02

  The invention relates to methods and compositions for the selection of patients for therapy with an anti-inflammatory drug. More particularly, the invention relates to compositions comprising folate-imaging agent conjugates for the selection of patients for therapy with an anti-inflammatory drug, and methods and uses therefor.

  本发明涉及选择患者接受抗炎药物治疗的方法和组合物。更具体地说，本发明涉及由叶酸成像剂共轭物组成的组合物，用于选择接受抗炎药物治疗的患者，及其方法和用途。
• US20140271476A1
  申请人：——

  公开号：US20140271476A1

  公开（公告）日：2014-09-18
• US20140271484A1
  申请人：——

  公开号：US20140271484A1

  公开（公告）日：2014-09-18