4-(1H-imidazol-2-yl)-butylamine | 41306-85-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(1H-imidazol-2-yl)-butylamine
• 英文别名: 4-(1H-imidazol-2-yl)butan-1-amine
• CAS: 41306-85-8
• 化学式: C₇H₁₃N₃
• 分子量: 139.2
• InChiKey: IMDBGSYBIGYHOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Methylthio-2-nitro-1-<3-<3-(1-piperidinylmethyl)-phenoxy>-propylamino>-ethen 、 4-(1H-imidazol-2-yl)-butylamine 反应 4.0h， 以58%的产率得到
  参考文献：
  名称：

  Buschauer; Postius; Szelenyi, Arzneimittel-Forschung/Drug Research, 1985, vol. 35, # 7, p. 1025 - 1029

  摘要：

  DOI：

文献信息

• 3-heteroalkyl-2,4.quinzaoline-diones
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0293500A1

  公开（公告）日：1988-12-07

  A compound is described which is selected from the group consisting of those of the formula: wherein A is a divalent moiety of the formula: or and n is an integer from 2-10, inclusive; R is hydrogen, oxygen or alkyl having from one to four carbon atoms; Z is C or N; and when Z is N, --- is ――― and there is no R substituent, when Z is C and R is oxygen, --- is ―――; and when Z is C and R is alkyl, --- is ――― ; R6 is hydrogen or alkyl having from one to four carbon atoms; R1 and R2 may be the same or different and may be selected from the group consisting of hydrogen, halogen, trifluoromethyl, alkoxy having from one to four carbon atoms, alkyl having from one to four carbon atoms, nitro and amino; wherein Heteroaryl is wherein R3 and R4 may be selected from hydrogen, alkyl having from one to four carbon atoms, or phenyl; and X is CH or N, together with the pharmaceutically acceptable salts thereof as well as a process for producing the same and its use for pharmaceutical processes.

  描述了一种化合物，所选自以下组合中的一种，其化学式为：其中A是化学式的二价基团：或者n为2-10之间的整数；R为氢、氧或具有1-4个碳原子的烷基；Z为C或N；当Z为N时，---为―――且没有R取代基，当Z为C且R为氧时，---为―――；当Z为C且R为烷基时，---为―――；R6为氢或具有1-4个碳原子的烷基；R1和R2可以相同也可以不同，可选自氢、卤素、三氟甲基、具有1-4个碳原子的烷氧基、具有1-4个碳原子的烷基、硝基和氨基；其中Heteroaryl为其中R3和R4可以选择自氢、具有1-4个碳原子的烷基或苯基；X为CH或N，以及其药学上可接受的盐，以及用于生产该化合物的过程及其在制药过程中的应用。
• Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists
  申请人：——

  公开号：US20020082272A1

  公开（公告）日：2002-06-27

  The present invention discloses novel substituted imidazole compounds which have H 3 receptor antagonist activity or dual histamine-H 1 and H 3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazoles as well as methods of using them to treat allergy, congestion, inflammatory and CNS-related diseases and others.

  本发明公开了新型的取代咪唑化合物，具有H3受体拮抗活性或双重组织胺-H1和H3受体拮抗活性，以及制备这些化合物的方法。在另一实施例中，本发明公开了包含这些咪唑类化合物的药物组合物，以及使用它们治疗过敏、充血、炎症和中枢神经系统相关疾病等方法。
• Heterocyclic compounds, their preparation and, pharmaceutical compositions containing them
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0237138A1

  公开（公告）日：1987-09-16

  A heterocyclic compound selected from those of formula (1), tautomers thereof, and pharmaceutically acceptable salts and esters of formula (I) compounds and tautomers: wherein A represents an alkylene or alkenylene chain which has 1 to 4 carbon atoms and which may have a hetero atom; B, D and Y are selected independently from oxygen and sulfur atoms and NH; R' and R2 are selected independently from hydrogen and halogen atoms and C, to C5 alkyl, C, to C5 alkoxy, C, to C5 alkylthio, phenyl, nitro, hydroxyl, sulfo, imidazolyl-C2 to C5 acylamimo, amino and carboxyl groups; and R3 represents a hydrogen atom, an amino group, a C1 to C5 alkyl group which may be substituted by a carboxyl group, or a phenyl group which may be substituted by a carboxyl, a carboxy-C1 to C5 alkyl, or an imidazolyl-C, to C5 alkylamide group. These compounds, particularly when D is oxygen, are aldose reductose inhibitors useful in treatment of chronic diabetic complications.

  选自式(1)的杂环化合物、其同系物以及式(I)化合物和同系物的药学上可接受的盐和酯： 其中 A 代表具有 1 至 4 个碳原子且可能具有杂原子的亚烷基或烯基链；B、D 和 Y 独立选自氧原子、硫原子和 NH；R'和 R2 独立选自氢原子、卤素原子和 C 至 C5 烷基、C 至 C5 烷氧基、C 至 C5 硫代烷基、苯基、硝基、羟基、磺基、咪唑基-C2 至 C5 氨基酰基、氨基和羧基；R3 代表氢原子、氨基、可被羧基取代的 C1 至 C5 烷基或可被羧基、羧基-C1 至 C5 烷基或咪唑基-C1 至 C5 烷酰胺基取代的苯基。这些化合物，特别是当 D 为氧时，是醛糖还原糖抑制剂，可用于治疗慢性糖尿病并发症。
• Phthalocyanine cyan dye with appended chelating arm to induce monomer dye formation and increased chroma
  申请人：Hewlett-Packard Company

  公开号：EP1270677A2

  公开（公告）日：2003-01-02

  The novel phthalocyanine cyan dye of the formula (I) in which M represents an ion of a metal selected from Cu, Fe, Co, Mg, Mn, Sn and Ni, X represents a linear compound having 6-10 atoms in length containing C, O, and/or N, R1 represents pyridine, imidazole, sulfide, thiol, phenol, benzene, benzaldehyde, pyrimidine, pyrizine, triazine, imidazole, thiazole, oxazole, pyridone, pyrone, pyrole, thiophene, furan, pyran, dioxane, and morpholine, and derivatives thereof, R2 represents an atom or chemical group that imparts water solubility to the phthalocyanine cyan dye, and y and z each independently represent an integer of 1 to 3 satisfying the relation of 2≤y+z≤4. Ink formulations containing at least one dye of the formula (I) and methods for ink jet printing with inks containing the phthalocyanine cyan dyes of formula (I).

  式 (I) 的新型酞菁青染料 其中 M 代表选自 Cu、Fe、Co、Mg、Mn、Sn 和 Ni 的金属离子，X 代表长度为 6-10 个原子、含有 C、O 和/或 N 的线性化合物、 R1 代表吡啶、咪唑、硫化物、硫醇、苯酚、苯、苯甲醛、嘧啶、吡嗪、三嗪、咪唑、噻唑、噁唑、吡啶酮、吡咯、噻吩、呋喃、吡喃、二噁烷和吗啉及其衍生物、 R2 代表使酞菁青染料具有水溶性的原子或化学基团，以及 y 和 z 各自独立地代表 1 至 3 的整数，满足 2≤y+z≤4 的关系。 含有至少一种式(I)染料的油墨配方和使用含有式(I)酞菁青染料的油墨进行喷墨打印的方法。
• Phthalocyanine cyan dye with appended chelating arm to inducemonomer dye formation and increased chroma
  申请人：——

  公开号：US20030041775A1

  公开（公告）日：2003-03-06

  The novel phthalocyanine cyan dye of the formula (I) 1 in which M represents an ion of a metal selected from Cu, Fe, Co, Mg, Mn, Sn and Ni, X represents a linear compound having 6-10 atoms in length containing C, 0, and/or N, R 1 represents pyridine, imidazole, sulfide, thiol, phenol, benzene, benzaldehyde, pyrimidine, pyrizine, triazine, imidazole, thiazole, oxazole, pyridone, pyrone, pyrole, thiophene, furan, pyran, dioxane, and morpholine, and derivatives thereof, R 2 represents an atom or chemical group that imparts water solubility to the phthalocyanine cyan dye, and y and z each independently represent an integer of 1 to 3 satisfying the relation of 2≦y+z≦4. Ink formulations containing at least one dye of the formula (I) and methods for ink jet printing with inks containing the phthalocyanine cyan dyes of formula (I).

  式 (I) 的新型酞菁青染料 1 其中 M 代表选自 Cu、Fe、Co、Mg、Mn、Sn 和 Ni 的金属离子，X 代表长度为 6-10 个原子、含有 C、0 和/或 N 的线性化合物、 R 1 代表吡啶、咪唑、硫化物、硫醇、苯酚、苯、苯甲醛、嘧啶、吡嗪、三嗪、咪唑、噻唑、噁唑、吡啶酮、吡喃酮、吡咯、噻吩、呋喃、吡喃、二噁烷和吗啉及其衍生物、 R 2 代表赋予酞菁青染料水溶性的原子或化学基团，以及 y 和 z 各自独立地代表 1 至 3 的整数，满足 2≦y+z≦4 的关系式。 含有至少一种式(I)染料的油墨配方和使用含有式(I)酞菁青染料的油墨进行喷墨打印的方法。