(2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol;2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol;2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide
• 化学式: C36H51N3O7
• 分子量: 637.8
• InChiKey: IZZOEKZUVZILNB-QAPYTUFNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.77
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  178
• 氢给体数：
  8
• 氢受体数：
  9

文献信息

• Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US10668094B2

  公开（公告）日：2020-06-02

  Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.

  本文提供的是α2-选择性Na,K-ATP酶抑制剂及其原药，其特征在于环状分子与地高辛或地高辛衍生物相连，以及其在降低眼压和治疗青光眼及心脏病方面的用途。
• INTRAOCULAR PHYSIOLOGICAL SENSOR
  申请人：Dose Medical Corporation

  公开号：EP2967326A1

  公开（公告）日：2016-01-20
• SYSTEMS AND METHODS FOR DELIVERING AN OCULAR IMPLANT TO THE SUPRACHOROIDAL SPACE WITHIN AN EYE
  申请人：Glaukos Corporation

  公开号：EP2967993A1

  公开（公告）日：2016-01-20
• SELECTIVE INHIBITORS OF Alpha2-CONTAINING ISOFORMS OF Na,K-ATPase AND USE THEREOF FOR REDUCTION OF INTRAOCULAR PRESSURE
  申请人：Yeda Research and Development Co., Ltd.

  公开号：US20180207189A1

  公开（公告）日：2018-07-26

  Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.
• [EN] SYSTEMS AND METHODS FOR DELIVERING AN OCULAR IMPLANT TO THE SUPRACHOROIDAL SPACE WITHIN AN EYE<br/>[FR] SYSTÈMES ET PROCÉDÉS POUR METTRE EN PLACE UN IMPLANT OCULAIRE DANS L'ESPACE SUPRA-CHOROÏDIEN DANS UN ŒIL
  申请人：GLAUKOS CORP

  公开号：WO2014151070A1

  公开（公告）日：2014-09-25

  Delivery devices, systems and methods are provided for inserting an implant into an eye. The delivery or inserter devices or systems can be used to dispose or implant an ocular stent or implant, such as a shunt, in communication with a suprachoroidal space of the eye. The implant can drain fluid from an anterior chamber of the eye to a physiologic outflow path of the eye, such as, the suprachoroidal space or other portion of the uveoscleral outflow path. The delivery or inserter devices or systems can be used in conjunction with other ocular surgery, for example, but not limited to, cataract surgery- through a preformed corneal incision, or independently with the inserter configured to make a corneal incision. The implant can be preloaded with or within the inserter to advantageously provide a sterile, easy-to-use package for use by an operator.