2,4-dioxo-1H-benzo[h]quinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2,4-dioxo-1H-benzo[h]quinoline-3-carboxylic acid
• 化学式: C₁₄H₉NO₄
• 分子量: 255.22
• InChiKey: AMXJDONUDUINFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SELECTIVE UV CROSSLINKING OF PEPTIDES AND FUNCTIONAL MOIETIES TO IMMUNOGLOBULINS
  申请人：UNIVERSITY OF NOTRE DAME DU LAC

  公开号：US20160022834A1

  公开（公告）日：2016-01-28

  The invention provides for a method of crosslinking a hetero-bifunctional photo crosslinking compound to an immunoglobulin having at least one heterocyclic photo reactive group and at least one non-photo reactive group where the non-photo reactive group is coupled to an effector molecule and the photo reactive group is coupled to the nucleotide binding site of an immunoglobulin. Alternatively, the photo crosslinker contains an orthogonal reactive group such as a thiol, which can be coupled to an effector molecule or functionalized ligand.

  该发明提供了一种将异双功能光交联化合物交联到至少具有一个杂环光反应基团和至少一个非光反应基团的免疫球蛋白的方法，其中非光反应基团与效应分子偶联，光反应基团与免疫球蛋白的核苷酸结合位点偶联。或者，光交联剂包含一个正交反应基团，例如硫醇，可以与效应分子或功能化配体结合。
• Selective UV crosslinking of peptides and functional moieties to immunoglobulins
  申请人：University of Notre Dame du Lac

  公开号：US11116848B2

  公开（公告）日：2021-09-14

  A method of crosslinking a hetero-bifunctional photo crosslinking compound to an immunoglobulin having at least one heterocyclic photo reactive group and at least one non-photo reactive group where the non-photo reactive group is coupled to an effector molecule and the photo reactive group is coupled to the nucleotide binding site of an immunoglobulin. Alternatively, the photo crosslinker contains an orthogonal reactive group such as a thiol, which can be coupled to an effector molecule or functionalized ligand.

  一种将杂双官能团光交联化合物与具有至少一个杂环光反应基团和至少一个非光反应基团的免疫球蛋白交联的方法，其中非光反应基团与效应分子偶联，光反应基团与免疫球蛋白的核苷酸结合位点偶联。或者，光交联剂含有一个正交反应基团，如硫醇，可与效应分子或功能化配体偶联。
• [EN] SELECTIVE UV CROSSLINKING OF PEPTIDES AND FUNCTIONAL MOIETIES TO IMMUNOGLOBULINS<br/>[FR] RÉTICULATION UV SÉLECTIVE DE PEPTIDES ET DE FRACTIONS FONCTIONNELLES AVEC DES IMMUNOGLOBULINES
  申请人：UNIV NOTRE DAME DU LAC

  公开号：WO2014152801A1

  公开（公告）日：2014-09-25

  The invention provides for a method of crosslinking a hetero-bifunctional photo crosslinking compound to an immunoglobulin having at least one heterocyclic photo reactive group and at least one non-photo reactive group where the non-photo reactive group is coupled to an effector molecule and the photo reactive group is coupled to the nucleotide binding site of an immunoglobulin. Alternatively, the photo crosslinker contains an orthogonal reactive group such as a thiol, which can be coupled to an effector molecule or functionalized ligand.