2-[3-[(1S)-1-(dimethylamino)ethyl]phenyl]ethyl-methylcarbamic acid

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[3-[(1S)-1-(dimethylamino)ethyl]phenyl]ethyl-methylcarbamic acid
• 化学式: C₁₄H₂₂N₂O₂
• 分子量: 250.34
• InChiKey: DPKDIBBYOMMLEG-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TRANSDERMAL DELIVERY OF TERTIARY AMINE DRUGS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR ADMINISTRATION TRANSDERMIQUE DE MÉDICAMENTS À BASE D'AMINE TERTIAIRE
  申请人：NOVEN PHARMA

  公开号：WO2014151492A1

  公开（公告）日：2014-09-25

  Described are transdermal drug delivery systems for the transdermal administration of tertiary amine drugs, such as rivastigmine, fentanyl or rotigotine, comprising a polymer matrix comprising a free base form of the drug and at least one carboxyl group-containing compound. In some embodiments, the systems include a rate-controlling membrane and a skin-contacting face adhesive apart from the polymer matrix.