[4-[2-[4-[(2S)-2-ethoxy-3-[methoxy(methyl)amino]-3-oxopropyl]phenoxy]ethyl]phenyl] methanesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: [4-[2-[4-[(2S)-2-ethoxy-3-[methoxy(methyl)amino]-3-oxopropyl]phenoxy]ethyl]phenyl] methanesulfonate
• 化学式: C₂₂H₂₉NO₇S
• 分子量: 451.5
• InChiKey: OJUXYDSDHTUKMW-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  99.8
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• PPAR-SPARING COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES
  申请人：METABOLIC SOLUTIONS DEVELOPMENT CO., LLC

  公开号：US20160152570A1

  公开（公告）日：2016-06-02

  The present invention relates to hydroxamate compounds and pharmaceutical compositions that are useful for treating and/or preventing metabolic inflammation mediated diseases such as diabetes, obesity, hypertension, dyslipidemia, a neurodegenerative disorder (e.g., Alzheimer's disease, Parkinson's disease, or Huntington's disease), or any combination thereof. Moreover, the present invention also provides methods of treatment for these diseases or disorders.

  本发明涉及羟酰胺化合物和药物组合物，其对于治疗和/或预防代谢性炎症介导的疾病如糖尿病、肥胖症、高血压、血脂异常、神经退行性疾病（例如阿尔茨海默病、帕金森病或亨廷顿病）或任何这些疾病的组合具有用处。此外，本发明还提供了治疗这些疾病或疾病的方法。
• US9562012B2
  申请人：——

  公开号：US9562012B2

  公开（公告）日：2017-02-07
• [EN] PPAR-SPARING COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES<br/>[FR] COMPOSÉS ÉPARGNANT LES PPAR POUR LE TRAITEMENT DE MALADIES MÉTABOLIQUES
  申请人：METABOLIC SOLUTIONS DEV CO LLC

  公开号：WO2015013187A1

  公开（公告）日：2015-01-29

  The present invention relates to hydroxamate compounds and pharmaceutical compositions that are useful for treating and/or preventing metabolic inflammation mediated diseases such as diabetes, obesity, hypertension, dyslipidemia, a neurodegenerative disorder (e.g., Alzheimer's disease, Parkinson's disease, or Huntington's disease), or any combination thereof. Moreover, the present invention also provides methods of treatment for these diseases or disorders.