3-Thiolquinuclidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: 3-Thiolquinuclidine
• 英文别名: 1-azabicyclo[2.2.2]octane-3-thione
• 化学式: C₇H₁₁NS
• 分子量: 141.24
• InChiKey: KVVHHFBFRAYBKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PREPARATION METHOD FOR AZOXYSTROBIN
  申请人：NUTRICHEM COMPANY LIMITED

  公开号：US20160090365A1

  公开（公告）日：2016-03-31

  Disclosed in the present invention is a preparation method of azoxystrobin having a structure as shown by formula (1), the method comprising: a) performing an etherification reaction by reacting the compound having a structure shown by formula (2) with 2-cyanophenol and/or a salt thereof under the catalysis of an azabicyclo tertiary amine compound and/or a salt thereof as the catalyst in a butyl acetate medium to obtain a butyl acetate solution containing azoxystrobin; and b) cooling the butyl acetate solution containing azoxystrobin to precipitate Azoxystrobin having a structure as shown by formula (1) from the butyl acetate solution. Using the method provided by the present invention to prepare azoxystrobin can significantly improve the yield of azoxystrobin, and can obtain azoxystrobin products having high purity.

  本发明揭示了一种具有式（1）所示结构的氧化亚菌灵的制备方法，该方法包括：a）通过在丁酸丁酯介质中以氮杂双环三级胺化合物和/或其盐作为催化剂，将具有式（2）所示结构的化合物与2-氰基苯酚和/或其盐反应进行醚化反应，以获得含有氧化亚菌灵的丁酸丁酯溶液；和b）将含有氧化亚菌灵的丁酸丁酯溶液冷却，从丁酸丁酯溶液中沉淀具有式（1）所示结构的氧化亚菌灵。使用本发明提供的方法制备氧化亚菌灵可以显著提高氧化亚菌灵的产率，并可以获得高纯度的氧化亚菌灵产品。
• PREPARATION METHOD OF AZOXYSTROBIN
  申请人：Nutrichem Company Limited

  公开号：EP2998299A1

  公开（公告）日：2016-03-23

  Disclosed in the present invention is a preparation method of azoxystrobin having a structure as shown by formula (1), the method comprising: a) performing an etherification reaction by reacting the compound having a structure shown by formula (2) with 2-cyanophenol and/or a salt thereof under the catalysis of an azabicyclo tertiary amine compound and/or a salt thereof as the catalyst in a butyl acetate medium to obtain a butyl acetate solution containing azoxystrobin; and b) cooling the butyl acetate solution containing azoxystrobin to precipitate Azoxystrobin having a structure as shown by formula (1) from the butyl acetate solution. Using the method provided by the present invention to prepare azoxystrobin can significantly improve the yield of azoxystrobin, and can obtain azoxystrobin products having high purity.

  本发明公开了一种具有式（1）所示结构的唑啉草酯的制备方法，该方法包括：a) 在氮杂双环叔胺化合物和/或其盐作为催化剂的催化下，在乙酸丁酯介质中通过使具有式（2）所示结构的化合物与 2-氰基苯酚和/或其盐反应进行醚化反应，以获得含有唑啉草酯的乙酸丁酯溶液；以及 b) 冷却含有唑啉草酯的乙酸丁酯溶液，从乙酸丁酯溶液中析出具有式（1）所示结构的唑啉草酯。使用本发明提供的方法制备唑啉草酯可显著提高唑啉草酯的收率，并可获得高纯度的唑啉草酯产品。
• US9611226B2
  申请人：——

  公开号：US9611226B2

  公开（公告）日：2017-04-04