5-羟基多巴胺 | 1927-04-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 5-羟基多巴胺
• 英文名称: 5-hydroxydopamine
• 英文别名: 5-(2-aminoethyl)benzene-1,2,3-triol；3,4,5-trihydroxyphenethylamine；6-hydroxydopamine；5-(2-amino-ethyl)-pyrogallol；3.4.5-Trihydroxy-phenaethylamin；5-(2-Amino-aethyl)-pyrogallol
• CAS: 1927-04-4
• 化学式: C₈H₁₁NO₃
• mdl: MFCD06654526
• 分子量: 169.18
• InChiKey: LCAINUZZHIZKKS-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  86.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-羟基多巴胺 在 氢氧化钾 、 vinyloxyl 作用下， 以 水 、 乙二醇 为溶剂， 生成
  参考文献：
  名称：

  酚的单电子氧化还原电位。具有生物学意义的羟基和氨基酚及相关化合物

  摘要：

  DOI：

  10.1021/j100215a033
• 作为产物：
  描述：

  仙人球毒碱 在 盐酸 作用下， 生成 5-羟基多巴胺
  参考文献：
  名称：

  Hahn; Rumpf, Chemische Berichte, 1938, vol. 71, p. 2141,2147

  摘要：

  DOI：

文献信息

• Synthesis of Tripodal Catechol Derivatives Having an Adamantyl Basic Framework for Functionalizing Surfaces
  申请人：Maison Wolfgang

  公开号：US20130245269A1

  公开（公告）日：2013-09-19

  The present invention describes tripodal catechol derivatives with an adamantyl basic framework for the functionalisation of surfaces, methods for their production and use. The remaining fourth bridgehead position is easily suitable to be further functionalised via so-called click reactions, by way of example with biomolecules, dyes, radiomarkers, polyethylene glycol or active agents. The compounds according to the present invention have the general formula X-Ad[(CH 2 ) n —YZ] 3 , wherein A stands for the adamantyl skeleton, X stands for a group —(CH 2 ) p —R 5 , wherein p=0 to 10 and R 5 is selected from —H, —NH 2 , —NO 2 , —OH, —SH, —O—NH 2 , —NH—NH 2 , —N═C═S—, —N═C═O—, —CH═CH 2 , —C≡CH, —COOH, —(C═O)H, —(C═O)R 6 Y stands for —CH 2 —, —CH═CH—, —O—, —S—, —S—S—, —NH—, —O—NH—, —NH—O—, —HC═N—O—, —O—N═CH—, —NR 1 —, -aryl-, -heteroaryl-, —(C═O)—, —O—(C═O)—, —(C═O)—O—, —NH—(C═O)—, —(C═O)—NH—, —NR 1 —(C═O)—, —(C═O)—NR 1 —, —NH—(C═O)—NH—, —NH—(C═S)—NH—, R 1 stands for an alkyl group, R 6 for an alkyl, alkenyl, alkynyl, aryl or heteroaryl group, and Z stands for a catechol derivative. The production of the compounds occurs by reacting a compound X-Ad[(CH 2 ) n —Y′] 3 with a reagent Y″Z to the corresponding compound X-Ad[(CH 2 ) n —YZ] 3 and subsequently purifying the reaction product. Y′ and Y″ are hereby precursors of Y. The compounds according to formula (I) according to the present invention are suitable to be used in a method to functionalise surfaces. The X group of the compounds according to the present invention is suitable to be optionally coupled to an effector, for example, by means of click chemistry.

  本发明描述了具有金刚烷基框架的三脚脚脚酚衍生物，用于功能化表面，以及它们的生产和使用方法。剩余的第四桥头位易于通过所谓的点击反应进一步功能化，例如与生物分子、染料、放射标记物、聚乙二醇或活性剂等。根据本发明的化合物具有一般公式X-Ad[(CH2)n—YZ]3，其中A代表金刚烷骨架，X代表一个基团—(CH2)p—R5，其中p=0到10，R5选自—H、—NH2、—NO2、—OH、—SH、—O—NH2、—NH—NH2、—N═C═S—、—N═C═O—、—CH═CH2、—C≡CH、—COOH、—(C═O)H、—(C═O)R6，Y代表—CH2—、—CH═CH—、—O—、—S—、—S—S—、—NH—、—O—NH—、—NH—O—、—HC═N—O—、—O—N═CH—、—NR1—、-芳基-、-杂环基-、—(C═O)—、—O—(C═O)—、—(C═O)—O—、—NH—(C═O)—、—(C═O)—NH—、—NR1—(C═O)—、—(C═O)—NR1—、—NH—(C═O)—NH—、—NH—(C═S)—NH—，R1代表烷基基团，R6代表烷基、烯基、炔基、芳基或杂环基，Z代表一个邻苯二酚衍生物。化合物的制备通过将化合物X-Ad[(CH2)n—Y′]3与试剂Y″Z反应形成相应的化合物X-Ad[(CH2)n—YZ]3，然后纯化反应产物。Y′和Y″是Y的前体。根据本发明的公式(I)的化合物适用于用于功能化表面的方法中。根据本发明的化合物的X基团适用于可选择地与效应物耦合，例如通过点击化学方法。
• Synthesis of phenethylamines from phenylacetonitriles obtained by alkylation of cyanide ion with mannich bases from phenols and other benzylamines
  作者：J.H. Short、D.A. Dunnigan、C.W. Ours

  DOI：10.1016/0040-4020(73)80127-9

  日期：1973.1

  alkylating agents. With such compounds it was necessary to prepare the quaternary salts before alkylation could be achieved. 6-Hydroxydopamine was prepared from 2,4,5-trimethoxybenzaldehyde utilizing the latter approach. 3,5-Dimethoxy-4-hydroxyphenethylamine was cyclized to the corresponding dihydroisoquinoline. The isoquinoline and tetrahydroisoquinoline analogs were also prepared. 4-Hydroxy-3-met

  通过在酚上进行曼尼希反应或通过醛的还原烷基化获得的苄胺已代替苄基氯用于氰化氰离子化，从而获得可还原为苯乙胺的腈。来自伯，仲和叔胺的4-羟基-3-甲氧基苯基乙腈的产率大致相同。没有邻位或对位的苄胺OH基团不充当烷基化剂。对于此类化合物，必须先制备季盐，然后才能实现烷基化。使用后一种方法由2,4,5-三甲氧基苯甲醛制备6-羟基多巴胺。将3，5-二甲氧基-4-羟基苯乙胺环化为相应的二氢异喹啉。还制备了异喹啉和四氢异喹啉类似物。将4-羟基-3-甲氧基苯基乙腈水解为高香草酸，即多巴胺的天然代谢产物。
• Synthesis of Trivalent Flexible Frameworks with Ligands Comprising Catechol Units for Functionalizing Surfaces
  申请人：Maison Wolfgang

  公开号：US20130245270A1

  公开（公告）日：2013-09-19

  The present invention describes tripodal catechol derivatives with a flexible basic framework for the functionalisation of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. The remaining fourth bridgehead position is easily suitable to be further functionalised via so-called click reactions, e.g. with biomolecules, dyes, radiomarkers, polyethylene glycol or active agents. The compounds according to the present invention have the general formula X—C[(CH 2 ) n —YZ] 3 , wherein X stands for a group —(CH 2 ) p —R 5 , wherein p=0 to 10 and R 5 is selected from —H, —NH 2 , —NO 2 , —OH, —SH, —O—NH 2 , —NH—NH 2 , —N═C═S—, —N═C═O—, —CH═CH 2 , —C≡CH, —COOH, —(C═O)H, —(C═O)R 6 Y stands for —CH 2 —, —CH═CH—, —C≡C—, —O—, —S—, —S—S—, —NH—, —O—NH—, —NH—O—, —HC═N—O—, —O—N═CH—, —NR 1 —, -Aryl-, -Heteroaryl-, —(C═O)—, —O—(C═O)—, —(C═O)—O—, —NH—(C═O)—, —(C═O)—NH—, —NR 1 —(C═O)—, —(C═O)—NR 1 —, —NH—(C═O)—NH—, —NH—(C═S)—NH—, R 1 stands for an aryl group, R 6 for an alkyl, alkenyl, alkynyl, aryl or heteroaryl group, and Z stands for a catechol derivative. The production of the compounds occurs by reacting a compound X—C[(CH 2 ) n —Y′] 3 with a reagent Y″Z to the corresponding compound X—C[(CH 2 ) n —YZ] 3 and subsequent purification of the reaction product. Y′ and Y″ are hereby precursors of Y. The compounds according to formula (I) according to the present invention are suitable to be used in a method to functionalize surfaces. The X group of the compounds according to the present invention is suitable to be optionally coupled to an effector, for example, by means of click chemistry.

  本发明描述了具有灵活基础结构的三脚猫二酚衍生物，用于表面功能化的方法及其生产和使用方法。灵活框架的中心原子是三级脂肪碳原子。剩余的第四个桥头位置易于通过所谓的点击反应进一步功能化，例如与生物分子、染料、放射性标记物、聚乙二醇或活性剂等进行反应。本发明中的化合物具有一般式X—C[(CH2)n—YZ]3，其中X代表一个群体—(CH2)p—R5，其中p=0至10，R5选自—H、—NH2、—NO2、—OH、—SH、—O—NH2、—NH—NH2、—N═C═S—、—N═C═O—、—CH═CH2、—C≡CH、—COOH、—(C═O)H、—(C═O)R6；Y代表—CH2—、—CH═CH—、—C≡C—、—O—、—S—、—S—S—、—NH—、—O—NH—、—NH—O—、—HC═N—O—、—O—N═CH—、—NR1—、-芳基-、-杂芳基-、—(C═O)—、—O—(C═O)—、—(C═O)—O—、—NH—(C═O)—、—(C═O)—NH—、—NR1—(C═O)—、—(C═O)—NR1—、—NH—(C═O)—NH—、—NH—(C═S)—NH—，其中R1代表芳基，R6代表烷基、烯基、炔基、芳基或杂芳基，Z代表二酚衍生物。该化合物的生产是通过将化合物X—C[(CH2)n—Y']3与试剂Y"Z反应得到相应的化合物X—C[(CH2)n—YZ]3，然后纯化反应产物。Y'和Y"是Y的前体。根据本发明的公式（I）中的化合物适用于用于表面功能化的方法。本发明中化合物的X基团适用于通过点击化学手段可选地与效应物耦合。
• [EN] NGAL-BINDING SIDEROPHORES AND USE THEREOF TO TREAT IRON DEFICIENCY AND IRON OVERLOAD<br/>[FR] SIDÉROPHORES SE LIANT À NGAL ET UTILISATION DE CEUX-CI POUR TRAITER UNE CARENCE EN FER ET UNE SURCHARGE EN FER
  申请人：UNIV COLUMBIA

  公开号：WO2010033847A1

  公开（公告）日：2010-03-25

  The invention provides compositions comprising a lipocalin, such as NGAL, and a mammalian siderophore that are useful as iron chelators and iron donors. The invention also provides mammalian siderophore compounds of Formula (I): The invention further provides, methods of treatment and methods of diagnosis.

  本发明提供了包含脂联素（如NGAL）和哺乳动物铁载体的组合物，这些组合物可用作铁螯合剂和铁供体。本发明还提供了公式（I）的哺乳动物铁载体化合物。此外，本发明还提供了治疗方法和诊断方法。
• AQUEOUS COMPOSITIONS FOR HAIR TREATMENT COMPRISING POLYORGANOSILOXANES WITH POLYHYDROXYAROMATIC MOIETIES
  申请人：Momentive Performance Materials Inc.

  公开号：US20180346653A1

  公开（公告）日：2018-12-06

  This invention relates to aqueous compositions for hair treatment, comprising polyorganosiloxanes A) having di- and trihydroxy-substituted aromatic groups and at least one surfactant B) selected from cationic surfactants B1) and anionic surfactants B2) in a certain weight ratio of the surfactant B) to the polyorganosiloxane A), and said aqueous compositions having a certain pH. The invention further relates to hair treatment compositions, comprising said aqueous compositions and to hair treatment processes using said aqueous compositions or hair treatment compositions.

  本发明涉及用于头发处理的水基组合物，包括具有二羟基和三羟基取代芳基的聚有机硅氧烷A）和至少一种阳离子表面活性剂B1）和阴离子表面活性剂B2）中选择的表面活性剂B）在一定的重量比下与聚有机硅氧烷A）混合，并且所述水基组合物具有一定的pH值。本发明还涉及头发处理组合物，包括所述的水基组合物，以及使用所述的水基组合物或头发处理组合物进行头发处理的处理过程。