6-acetyl-1,3-dimethylperimidine-2-one | 58629-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类 - 二氮杂萘
• 英文名称: 6-acetyl-1,3-dimethylperimidine-2-one
• 英文别名: 6-acetyl-1,3-dimethylperimidone；6-Acetyl-1,3-dimethylperimidon；1,3-Dimethyl-6-acetylperimidon；6-acetyl-1,3-dimethyl-1H,3H-perimidin-2-one；6-acetyl-1,3-dimethyl-1H-perimidin-2(3H)-one；6-acetyl-1,3-dimethylperimidin-2-one
• CAS: 58629-26-8
• 化学式: C₁₅H₁₄N₂O₂
• 分子量: 254.288
• InChiKey: JYIDKRXDYHFZBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-acetyl-1,3-dimethylperimidine-2-one 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以90%的产率得到1,3-dimethyl-6-(1-hydroxyethyl)perimidine-2-one
  参考文献：
  名称：

  Resonance-stabilized α-naphthylmethyl carbocations and spiro compounds based thereon: VII. Transformations of α-naphthylmethyl carbocations stabilized by one electron-donor group or peri-fused heteroring

  摘要：

  1-Hydroxymethyl- and 1-alkoxymethylnaphthalenes containing dimethylamino and methoxy groups or a heteroring in positions 4 and 5 react with protic and Lewis acids to give 1-naphthylmethyl carbocations. Reactions of the latter with the initial alcohol molecule lead to the formation of oligomerization or dehydrogenation (to aldehyde) products or the corresponding dinaphthylmethanes. In some cases, the process was accompanied by cyclodimerization to form cyclohexadienone spiro derivatives in a small yield.

  DOI：

  10.1134/s107042800603002x
• 作为产物：
  描述：

  1-(1,3-dimethylperimidin-3-ium-6-yl)ethanone;iodide 、 氢氧化钾 以34%的产率得到
  参考文献：
  名称：

  BOROVLEV I. V.; POZHARSKIJ A. F.; KOROLEVA V. N., XIMIYA GETEROTSIKL. SOEDIN. , 1976, HO 12, 1692-1695

  摘要：

  DOI：

文献信息

• ——
  作者：I. V. Borovlev、O. P. Demidov、A. F. Pozharskii

  DOI：10.1023/a:1016001321161

  日期：——

  The regioselectivity of the reactions of perimidine with cinnamic acids in polyphosphoric acid (PPA) depends on the P2O5 content. Procedures were developed for the synthesis of 4(9)- and 6(7)-cinnamoylperimidines. Cyclization of the latter under the action of an excess of AlBr3 was accompanied by dearylation to form 6-hydroxy-1,3-diazapyrene.
• BOROVLEV I. V.; POZHARSKIJ A. F., XIMIYA GETEROTSIKL. SOEDIN. <KGSS-AQ>, 1975, HO 12, 1688-1691
  作者：BOROVLEV I. V.、 POZHARSKIJ A. F.

  DOI：——

  日期：——
• BOROVLEV I. V.; POZHARSKIJ A. F., XIMIYA GETEROTSIKL. SOEDIN., 1978, HO 6, 833-842
  作者：BOROVLEV I. V.、 POZHARSKIJ A. F.

  DOI：——

  日期：——
• Resonance-stabilized α-naphthylmethyl carbocations and spiro compounds based thereon: VII. Transformations of α-naphthylmethyl carbocations stabilized by one electron-donor group or peri-fused heteroring
  作者：O. V. Vinogradova、E. A. Filatova、N. V. Vistorobskii、A. F. Pozharskii、I. V. Borovlev、Z. A. Starikova

  DOI：10.1134/s107042800603002x

  日期：2006.3

  1-Hydroxymethyl- and 1-alkoxymethylnaphthalenes containing dimethylamino and methoxy groups or a heteroring in positions 4 and 5 react with protic and Lewis acids to give 1-naphthylmethyl carbocations. Reactions of the latter with the initial alcohol molecule lead to the formation of oligomerization or dehydrogenation (to aldehyde) products or the corresponding dinaphthylmethanes. In some cases, the process was accompanied by cyclodimerization to form cyclohexadienone spiro derivatives in a small yield.
• BOROVLEV I. V.; POZHARSKIJ A. F.; KOROLEVA V. N., XIMIYA GETEROTSIKL. SOEDIN. <KGSS-AQ>, 1976, HO 12, 1692-1695
  作者：BOROVLEV I. V.、 POZHARSKIJ A. F.、 KOROLEVA V. N.

  DOI：——

  日期：——