(Z)-3-methyl-N-[(Z)-(3-methyl-1,3-benzothiazol-3-ium-2-yl)diazenyl]-1,3-benzothiazol-2-imine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: (Z)-3-methyl-N-[(Z)-(3-methyl-1,3-benzothiazol-3-ium-2-yl)diazenyl]-1,3-benzothiazol-2-imine
• 化学式: C16H14N5S2+
• 分子量: 340.5
• InChiKey: WMKYHKIRADYFGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  97.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] ARYL AND HETEROARYL COMPOUNDS USEFUL AS FIBROBLAST GROWTH FACTOR ANTAGONISTS<br/>[FR] COMPOSES ARYLES ET HETEROARYLES UTILES COMME ANTAGONISTES DU FACTEUR DE CROISSANCE DES FIBROBLASTES (FGF)
  申请人：EISAI CO LTD

  公开号：WO2000030632A1

  公开（公告）日：2000-06-02

  Aryl and heteroaryl compounds, pharmaceutical compositions containing the compounds, and methods for using the pharmaceutical compositions for modulating the activity of the FGF family of peptides are provided. Methods for inhibiting the binding of an FGF peptide to an FGF receptor by contacting the receptor with the aromatic acid are also provided. Methods for treating FGF-mediated disorders by administering effective amounts of one or more of these compounds or pharmaceutically acceptable derivatives thereof that inhibit the activity of one or more FGF peptides are also provided.