4,5-dihydro-3-methyl-2H-furo[2,3-c]pyran-2-one | 1044244-95-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃吡喃类
• 英文名称: 4,5-dihydro-3-methyl-2H-furo[2,3-c]pyran-2-one
• 英文别名: 3-Methyl-4,5-dihydrofuro[2,3-c]pyran-2-one；3-methyl-4,5-dihydrofuro[2,3-c]pyran-2-one
• CAS: 1044244-95-2
• 化学式: C₈H₈O₃
• 分子量: 152.15
• InChiKey: KPGYWPOMHCAWDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl 2-(tetrahydro-5-oxo-2H-pyran-4-yl)-2-hydroxypropanoate 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以48%的产率得到4,5-dihydro-3-methyl-2H-furo[2,3-c]pyran-2-one
  参考文献：
  名称：

  Synthesis of the seed germination stimulant 3-methyl-2H-furo[2,3-c]pyran-2-ones utilizing direct and regioselective Ti-crossed aldol addition

  摘要：

  3-Methyl-2H-furo[2,3-c]pyran-2-ones 1 and 2, a unique and remarkable seed germination stimulant, and its analogue were synthesized using direct and regioselective Ti-crossed aldol addition between dihydro-2H-pyran-3(4H)-ones and methyl pyruvate as the key step, followed by furanone formation. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.052

文献信息

• Synthesis of the seed germination stimulant 3-methyl-2H-furo[2,3-c]pyran-2-ones utilizing direct and regioselective Ti-crossed aldol addition
  作者：Ryohei Nagase、Mayumi Katayama、Hiroaki Mura、Noritada Matsuo、Yoo Tanabe

  DOI：10.1016/j.tetlet.2008.05.052

  日期：2008.7

  3-Methyl-2H-furo[2,3-c]pyran-2-ones 1 and 2, a unique and remarkable seed germination stimulant, and its analogue were synthesized using direct and regioselective Ti-crossed aldol addition between dihydro-2H-pyran-3(4H)-ones and methyl pyruvate as the key step, followed by furanone formation. (c) 2008 Elsevier Ltd. All rights reserved.