dimethyl (4-(2-amino-4-morpholinopteridin-6-yl)phenyl)methylphosphonate | 1003845-07-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: dimethyl (4-(2-amino-4-morpholinopteridin-6-yl)phenyl)methylphosphonate
• 英文别名: Dimethyl P-[[4-[2-amino-4-(4-morpholinyl)-6-pteridinyl]phenyl]methyl]phosphonate；6-[4-(dimethoxyphosphorylmethyl)phenyl]-4-morpholin-4-ylpteridin-2-amine
• CAS: 1003845-07-5
• 化学式: C₁₉H₂₃N₆O₄P
• 分子量: 430.403
• InChiKey: GNKWIAUTXCLFDQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• SUBSTITUTED PTERIDINES USEFUL FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS
  申请人：Gilead Sciences, Inc.

  公开号：US20190152974A1

  公开（公告）日：2019-05-23

  The invention provides 4,6-di- and 2,4,6-tri-substituted pteridine derivatives with a specific substitution pattern which exhibit a significant and selective activity against certain types of viral infections, in particular selectively inhibit replication of Flaviridae such as the hepatitis C virus, and are useful for the prevention and treatment of such viral infections.