5-苯基异苯并呋喃-1,3-二酮 | 955-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 5-苯基异苯并呋喃-1,3-二酮
• 英文名称: 3,4-biphenyldicarboxylic anhydride
• 英文别名: 5-phenylisobenzofuran-1,3-dione；4-phenyl-phthalic acid-anhydride；4-Phenyl-phthalsaeure-anhydrid；4-phenyl phthalic anhydride；5-phenyl-2-benzofuran-1,3-dione
• CAS: 955-16-8
• 化学式: C₁₄H₈O₃
• 分子量: 224.216
• InChiKey: YTRAFABYXOZRDF-UHFFFAOYSA-N

物化性质

• 熔点：
  134-135 °C
• 沸点：
  436.5±24.0 °C(Predicted)
• 密度：
  1.335±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  5-苯基异苯并呋喃-1,3-二酮 在 尿素 作用下， 生成 5-苯基-1H-异吲哚-1,3(2H)-二酮
  参考文献：
  名称：

  Butterworth et al., Journal of the Chemical Society, 1938, p. 1386,1389

  摘要：

  DOI：
• 作为产物：
  描述：

  dimethyl 4-phenylphthalate 在 乙酸酐 作用下， 生成 5-苯基异苯并呋喃-1,3-二酮
  参考文献：
  名称：

  Formation of Cyclopent[a]indene and Acenaphthylene from Allyl Esters of Biphenyl Mono- and Di-carboxylic Acids and from Biphenyl Dicarboxylic Anhydrides on Flash Vacuum Pyrolysis at 1000 - 1100°C

  摘要：

  在 1000-1100°C 下闪速真空热解三种异构联苯羧酸的烯丙基酯 在 1000-1100°C 下闪速真空热解三种异构联苯羧酸的烯丙基酯、12 联苯二甲酸的烯丙基酯和三种联苯二甲酸酐的烯丙基酯 得到的热解产物通过 1H n.m.r. 光谱进行了检测。在所有情况下，光谱都显示 存在环戊并[a]茚和 苊烯和其他产物。这些 环收缩和环化过程的可能机制进行了讨论，并对 2,3-13C2]的热解结果。 联苯-2,3-二羧酸酐和 [3,4-13C2]和 (2-2 H1)-联苯-3,4-二羧酸酐的热解结果。 酐。

  DOI：

  10.1071/c97119

文献信息

• Method of producing dimethyl phthalate from naphthalene based chemicals
  申请人：COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

  公开号：US20040215035A1

  公开（公告）日：2004-10-28

  The present invention results to an improved and environment friendly method of producing dimethyl phthalate of about 99% purity from naphthalene based chemicals, said method comprising steps of mixing phthalic anhydride with methanol in the ratio ranging between 2:3 to 3:2, adding catalyst(s) to the mixture wherein, the ratio of phthalic anhydride and the catalyst is ranging between 3:1 to 15:1, adding a promoter to the resultant of step (b) wherein, the promoter is in the range of 1.5 to 2.0% by weight of phthalic anhydride, refluxing the resulted mixture at a temperature ranging between 60 to 100° C., for time duration ranging between 6 to 12 hrs. in the presence of benzene, wherein the ratio of benzene phthalic anhydride is in the range of 1:5 to 2:1 to obtain distillate, neutralizing the residue with about 10% caustic soda, extracting the neutralized residue with the benzene, distilling at the temperature ranging between 140 to 150° C. under 10 mm of mercury to obtain dimethyl phthalate.

  该发明涉及一种改进的环保方法，从基于萘的化学物质中生产约99%纯度的邻苯二甲酸二甲酯，所述方法包括以下步骤：将邻苯二甲酸酐与甲醇按比例混合，比例范围为2:3至3:2，向混合物中加入催化剂，其中邻苯二甲酸酐和催化剂的比例范围为3:1至15:1，向步骤(b)的产物中加入促进剂，其中促进剂的重量占邻苯二甲酸酐的1.5%至2.0%，在60至100°C的温度范围内回流混合物，时间范围为6至12小时，在苯的存在下，苯和邻苯二甲酸酐的比例范围为1:5至2:1，以获得馏分，用约10%的氢氧化钠中和残渣，用苯提取中和后的残渣，在10毫米汞柱下在140至150°C的温度范围内蒸馏，以获得邻苯二甲酸二甲酯。
• [EN] METHOD OF PRODUCING DIMETHYL PHTHALATE FROM NAPHTHALENE BASED CHEMICALS<br/>[FR] PROCEDE DE PRODUCTION DE PHTALATE DE DIMETHYLE A PARTIR DE SUBSTANCES CHIMIQUES A BASE DE NAPHTALENE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2004078699A1

  公开（公告）日：2004-09-16

  The present invention results to an improved and environment friendly method of producing dimethyl phthalate of about 99% purity from naphthalene based chemicals, said method comprising steps of mixing phthalic anhydride with methanol in the ratio ranging between 2:3 to 3:2, adding catalyst(s) to the mixture wherein, the ratio of phthalic anhydride and the catalyst is ranging between 3:1 to 15:1, adding a promoter to the resultant of step (b) wherein, the promoter is in the range of 1.5 to 2.0% by weight of phthalic anhydride, refluxing the resulted mixture at a temperature ranging between 60 to 100°C, for time duration ranging between 6 to 12 hrs. in the presence of benzene, wherein the ratio of benzene phthalic anhydride is in the range of 1:5 to 2:1 to obtain distillate, neutralizing the residue with about 10% caustic soda, extracting the neutralized residue with the benzene, distilling at the temperature ranging between 140 to 150°C under 10mm of mercury to obtain dimethyl phthalate.

  该发明涉及一种改进的环保方法，从基于萘的化学物质中生产约99%纯度的邻苯二甲酸二甲酯，所述方法包括以下步骤：将邻苯二甲酸酐与甲醇按比例混合，比例范围为2:3至3:2，在混合物中加入催化剂，其中邻苯二甲酸酐和催化剂的比例范围为3:1至15:1，在步骤(b)的结果中加入促进剂，其中促进剂的重量占邻苯二甲酸酐的1.5%至2.0%，在60至100°C的温度范围内回流混合物，时间范围为6至12小时，在苯的存在下，苯和邻苯二甲酸酐的比例范围为1:5至2:1以获得馏分，用约10%的氢氧化钠中和残渣，用苯提取中和后的残渣，在10毫米汞柱下在140至150°C的温度范围内蒸馏以获得邻苯二甲酸二甲酯。
• [EN] INHIBITORS OF PROTEIN ARGININE DEIMINASES (PADS) AND METHODS OF PREPARATION AND USE THEREOF<br/>[FR] INHIBITEURS DE PROTÉINE ARGININE DÉIMINASES (PAD) ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION ASSOCIÉS
  申请人：UNIV MASSACHUSETTS

  公开号：WO2018102262A1

  公开（公告）日：2018-06-07

  The invention provides novel inhibitors or inactivators of protein arginine deiminases, pharmaceutical compositions and methods of use thereof. The invention also relates to molecular probes based on such compounds and methods of use thereof.

  这项发明提供了新型的蛋白精氨酸去亚氨基酶抑制剂或失活剂，以及其药物组合物和使用方法。该发明还涉及基于这些化合物的分子探针以及其使用方法。
• Novel aromatic diamine and polyimide thereof
  申请人：Mitsui Chemicals, Inc.

  公开号：US20030092870A1

  公开（公告）日：2003-05-15

  The aromatic diamine compound of the present invention is represented by the following formula (1), and from the aromatic diamine compound a polyimide having a repeating unit represented by the following formula (4), which has low-temperature adherability, can be obtained. 1 In the formulas (1) and (4), n is an integer of 3 to 7, each R is independently an atom or a group selected from the group consisting of a hydrogen atom, a halogen atom and a hydrocarbon group, the same or different two hetero atoms selected from nitrogen atoms and oxygen atoms bonded to each benzene ring are at the ortho- or meta-positions to each other on at least one benzene ring, and when n is 3, the hetero atoms are at the ortho- or meta-positions to each other on all the benzene rings. In the formula (4), Y is a tetravalent organic group.

  本发明的芳香族二胺化合物由以下式(1)表示，从该芳香族二胺化合物可以得到具有低温粘附性的重复单元由以下式(4)表示的聚酰亚胺。 在式(1)和式(4)中，n是3到7的整数，每个R独立地是氢原子、卤素原子和烃基所选的原子或基团，所选的两个异原子从氮原子和氧原子中选择，它们与至少一个苯环上的另一个异原子连接在邻位或间位上，当n为3时，异原子在所有苯环上都在邻位或间位上。在式(4)中，Y是四价有机基团。
• Polyimides and polyamic acids
  申请人：——

  公开号：US20020182536A1

  公开（公告）日：2002-12-05

  A polyimide having a repeating unit of the general formula (I) and a polyamic acid having a repeating unit of the formula (IV): 1 (wherein, R 1 and R 2 represent H or a C1 to C20 alkyl group, and Z represents a condensed polycyclic aromatic group or an group of the following formulae: 2 Herein, X represents —CO— or —C(═N 2 )—, Y represents a direct bond, —CH 2 —, —O—, —SO 2 —, —S—, —CO— or —C(═N 2 )—, and W represents a direct bond, —CH 2 —, —C(CH 3 ) 2 —, —C(CF 3 ) 2 —, —S—, —SO—, —SO 2 — or —O—. b, m and n are 0 or 1; r is a C1 to 4 alkyl group, halogen group or phenyl group; a is 0 or 1 to 3.).

  具有通式(I)重复单元的聚酰亚胺和具有通式(IV)重复单元的聚酰胺酸：1（其中，R1和R2代表H或C1至C20烷基，Z代表缩聚的多环芳族基或以下式的基团：2，其中，X代表—CO—或—C(═N2)—，Y代表直接键，—CH2—，—O—，—SO2—，—S—，—CO—或—C(═N2)—，W代表直接键，—CH2—，—C(CH3)2—，—C(CF3)2—，—S—，—SO—，—SO2或—O—。b，m和n为0或1；r为C1至4烷基，卤素基或苯基；a为0或1至3。）