3,17,20-Trihydroxypregnane | 33995-20-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3,17,20-Trihydroxypregnane
• 英文别名: (8R,9S,10S,13S,14S,17R)-17-(1-hydroxyethyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol
• CAS: 33995-20-9
• 化学式: C₂₁H₃₆O₃
• 分子量: 336.5
• InChiKey: SCPADBBISMMJAW-JDIROBOTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Cholesterol-lowering agents, secondary bile acid production inhibitors and foods and drinks
  申请人：Sawada Haruji

  公开号：US20050244426A1

  公开（公告）日：2005-11-03

  Secondary bile acid production inhibitors and cholesterol-lowering agents containing a yeast as the active ingredient.

  含有酵母作为活性成分的次级胆汁酸生产抑制剂和降低胆固醇药物。
• Use of pregnane steroid derivatives for enhancing physical performance
  申请人：Marchewitz Eric

  公开号：US20060211667A1

  公开（公告）日：2006-09-21

  A method of increasing lean body mass in humans comprises administering a pregnane steroid derivative or a physiologically acceptable salt or ester thereof of the general formula: wherein R1=H and R2=H, or R1 and R2 combined form a single bond; R3 is one of OH and O; R5 is one of an α-hydrogen and a β-hydrogen; R6 is one of α-methyl and H; R7 is one of α-methyl and H; R17 is one of H and OH; and R20 is one of OH and O.
• METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER
  申请人：Haggerty Timothy J.

  公开号：US20140335050A1

  公开（公告）日：2014-11-13

  The invention features methods, compositions, and kits for the administration of an HSP90 inhibitor, OBAA, flunarizine, aphidicolin, damnacanthal, dantrolene, or an analog thereof, alone, or in combination with, e.g., a TAA, an antigen-binding scaffold (e.g., an antibody, a soluble T cell receptor, or a chimeric receptor) specific for a TAA, a cell (e.g., a white blood cell that targets a cancer cell), and/or an IFN-β receptor agonist or an IFN-γ receptor agonist, for the treatment of cancer.
• US5846954A
  申请人：——

  公开号：US5846954A

  公开（公告）日：1998-12-08
• US7101544B1
  申请人：——

  公开号：US7101544B1

  公开（公告）日：2006-09-05