5H-苯并[a]苯并噁嗪-5-酮,10-(2-氨基乙基)- | 114246-76-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 中文名称: 5H-苯并[a]苯并噁嗪-5-酮,10-(2-氨基乙基)-
• 英文名称: 10-(2-Aminoethyl)-5H-benzo[a]phenoxazin-5-one
• 英文别名: 5H-Benzo[a]phenoxazin-5-one, 10-(2-aminoethyl)-；10-(2-aminoethyl)benzo[a]phenoxazin-5-one
• CAS: 114246-76-3
• 化学式: C₁₈H₁₄N₂O₂
• 分子量: 290.321
• InChiKey: PLBZJWKDDGNTJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• COMPOSITIONS AND METHODS FOR BONE FORMATION AND MODELING
  申请人：ENZO Biochem, Inc.

  公开号：US20130172332A1

  公开（公告）日：2013-07-04

  The present disclosure is directed to methods of identifying a compound that binds to or interacts with a protein receptor involved in bone formation. Specifically, the disclosure is directed to methods of identifying a compound that regulates a Wnt pathway in a cell by binding to or interacting with cavities in proteins such as LRP5, LRP 6 and/or frizzled receptor and interfering with receptor binding to other proteins in a Wnt pathway. The present disclosure is further directed to methods and compositions that comprise an identified compound for treating or preventing a disease in a mammal in which Wnt pathway suppression plays a role.
• US8367822B2
  申请人：——

  公开号：US8367822B2

  公开（公告）日：2013-02-05
• US8969339B2
  申请人：——

  公开号：US8969339B2

  公开（公告）日：2015-03-03