3-Morpholino-1,2,4-triazol | 18377-89-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Morpholino-1,2,4-triazol
• 英文别名: 4-(1H-[1,2,4]triazol-3-yl)-morpholine；4-(1H-1,2,4-Triazol-3-yl)morpholine；4-(1H-1,2,4-triazol-5-yl)morpholine
• CAS: 18377-89-4
• 化学式: C₆H₁₀N₄O
• mdl: MFCD20547449
• 分子量: 154.172
• InChiKey: RDEXLPZSVFTQSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  54
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-Morpholin-4-yl-3H-[1,2,4]triazole-1,2-dicarboxylic acid diethyl ester 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以79%的产率得到3-Morpholino-1,2,4-triazol
  参考文献：
  名称：

  Cycloaddition of Synthetic Equivalent of Non-stabilized Aminonitrile Ylides: A New Route to Amino-substituted D2-Imidazolines and D3-1,2,4-Triazolines

  摘要：

  The N-unsubstituted nonstabilized azomethine ylides generated from the desilylation of N- [(trimethylsilyl)methyl]iminium triflates undergo successful cycloaddition to strongly polarized sulfonylimines and diethyl azodicarboxylate to produce the corresponding Delta (2)-imidazolines and Delta (3)-1,2,4-triazolines together with the initial cycloadducts. The initial cycloadducts are converted to the corresponding aminonitrile ylide cycloadducts. Thus the present process provides a new route to amino-substituted Delta (2)-imidazolines and Delta (3)-1,2,4-triazolines that are otherwise relatively inaccessible.

  DOI：

  10.3987/com-00-9121

文献信息

• [EN] NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES<br/>[FR] NOUVEAUX COMPOSÉS HÉTÉROARYLE-TRIAZOLE UTILISÉS COMME PESTICIDES
  申请人：BAYER AG

  公开号：WO2021069567A1

  公开（公告）日：2021-04-15

  The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, Y, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

  本发明涉及一种新型杂环基三唑化合物，其一般式为（I），其中结构元素X、Y、R1、R2、R3a、R3b、R4和R5的含义如描述中所示，以及包含这些化合物的配方和组合物，用于控制包括节肢动物和昆虫在内的动物害虫，用于植物保护，并用于控制动物体表寄生虫。
• 11-Beta HSD 1 inhibitors
  申请人：Xiang Shaoyun Jason

  公开号：US20070219198A1

  公开（公告）日：2007-09-20

  This invention relates to inhibiting 11βHSD1.

  该发明涉及抑制11βHSD1。
• 11-Beta HSD1 Inhibitors
  申请人：Xiang Jason Shaoyun

  公开号：US20100029648A1

  公开（公告）日：2010-02-04

  This invention relates to inhibiting 11βHSD1.

  本发明涉及抑制11βHSD1。
• COMPOUNDS AND COMPOSITIONS COMPRISING CDK INHIBITORS AND METHODS FOR TREATING CANCER
  申请人：Xu Wen Fang

  公开号：US20120121692A1

  公开（公告）日：2012-05-17

  Disclosed herein are compounds suitable for use as antitumor agents, methods for treating cancer wherein the disclosed compounds are used in making a medicament for the treatment of cancer, methods for treating a tumor comprising, administering to a subject a composition comprising one or more of the disclosed cytotoxic agents, and methods for preparing the disclosed antitumor agents.

  本文披露了适用于作为抗肿瘤剂的化合物，其中所披露的化合物用于制备用于治疗癌症的药物，治疗肿瘤的方法包括向受试者投与含有所披露的细胞毒性药物之一或多个的组合物，以及制备所披露的抗肿瘤剂的方法。
• Becker,H.G.O.; Eisenschmidt,V., Zeitschrift fur Chemie, 1968, vol. 8, # 3, p. 105 - 106
  作者：Becker,H.G.O.、Eisenschmidt,V.

  DOI：——

  日期：——