4-iodo-5-methyl-2,3-dihydrofuran | 1232199-33-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 4-iodo-5-methyl-2,3-dihydrofuran
• CAS: 1232199-33-5
• 化学式: C₅H₇IO
• 分子量: 210.014
• InChiKey: RPMVBPDMRQSFRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-戊炔-1-醇 在 iron(III) chloride hexahydrate 、 碘 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以80%的产率得到4-iodo-5-methyl-2,3-dihydrofuran
  参考文献：
  名称：

  FeCl₃-Mediated Reaction of Alkynols with Iodine: An Efficient and Convenient Synthetic Route to Vinyl Iodides

  摘要：

  [image omitted] The FeCl3-mediated reaction of alkynols with iodine resulted in intramolecular addition of hydroxyl to alkyne to produce a wide range of iodocycloenol ethers in good to excellent yields under mild reaction conditions. On the other hand, 1,2-diiodides were obtained in good yields when propargyl alcohol reacted with iodine in the same condition.

  DOI：

  10.1080/00397911.2010.481739

文献信息

• FeCl₃-Mediated Reaction of Alkynols with Iodine: An Efficient and Convenient Synthetic Route to Vinyl Iodides
  作者：Lei Su、Chun-Yan Lei、Wei-Yong Fan、Liang-Xian Liu

  DOI：10.1080/00397911.2010.481739

  日期：2011.3.28

  [image omitted] The FeCl3-mediated reaction of alkynols with iodine resulted in intramolecular addition of hydroxyl to alkyne to produce a wide range of iodocycloenol ethers in good to excellent yields under mild reaction conditions. On the other hand, 1,2-diiodides were obtained in good yields when propargyl alcohol reacted with iodine in the same condition.