6,7-二氢-5H-吡咯并[3,4-d]嘧啶-2-甲腈 | 947305-16-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 中文名称: 6,7-二氢-5H-吡咯并[3,4-d]嘧啶-2-甲腈
• 中文别名: 6,7-二氢-5H-吡咯[3,4-D]嘧啶-2-甲腈
• 英文名称: 6,7-Dihydro-5H-pyrrolo[3,4-D]pyrimidine-2-carbonitrile
• CAS: 947305-16-0
• 化学式: C₇H₆N₄
• mdl: MFCD11518984
• 分子量: 146.15
• InChiKey: XGULKVWYPKGQSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  tert-butyl 2-cyano-5H,6H,7H-pyrrolo[3,4-d]pyrimidine-6-carboxylate 在 silica 、 甲醇 、 二氯甲烷 作用下， 以 三氟乙酸 、 二氯甲烷 为溶剂， 以to yield 6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2-carbonitrile的产率得到6,7-二氢-5H-吡咯并[3,4-d]嘧啶-2-甲腈
  参考文献：
  名称：

  Aminocyclohexanes as Dipeptidyl Peptidase-IV for the Treatment or Prevention of Diabetes

  摘要：

  本发明涉及一种新型的取代氨基环己烷化合物，它们是二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂，可用于治疗或预防二肽基肽酶-IV酶参与的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶参与的疾病中使用这些化合物和组合物的方法。

  公开号：

  US20090105284A1

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AS HIV PROTEASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE LA PROTÉASE DU VIH
  申请人：MERCK SHARP & DOHME

  公开号：WO2018118829A1

  公开（公告）日：2018-06-28

  The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

  本发明涉及Formula I化合物、包含这些化合物的药物组合物，以及它们在抑制HIV蛋白酶、抑制HIV复制、预防HIV感染、治疗HIV感染以及预防、治疗和延缓艾滋病发病或进展中的用途。
• Aminocyclohexanes as Dipeptidyl Peptidase-IV for the Treatment or Prevention of Diabetes
  申请人：Biftu Tesfaye

  公开号：US20090105284A1

  公开（公告）日：2009-04-23

  The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及一种新型的取代氨基环己烷化合物，它们是二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂，可用于治疗或预防二肽基肽酶-IV酶参与的疾病，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶参与的疾病中使用这些化合物和组合物的方法。
• Aminotetrahydropyrans as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes
  申请人：Biftu Tesfaye

  公开号：US20100234403A1

  公开（公告）日：2010-09-16

  The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及结构式I的新型取代氨基四氢吡喃衍生物，其是二肽基肽酶IV酶的抑制剂，并且在治疗或预防涉及二肽基肽酶IV酶的疾病，例如糖尿病和特别是2型糖尿病中有用。本发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及二肽基肽酶IV酶的这些疾病中使用这些化合物和组合物。
• AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP1888066B1

  公开（公告）日：2012-01-11
• HETEROCYCLIC COMPOUNDS AS HIV PROTEASE INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP3558305A1

  公开（公告）日：2019-10-30