PtCl(NH3)(cyclohexylamine)(OH) | 889100-68-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: PtCl(NH3)(cyclohexylamine)(OH)
• 英文别名: azane;cyclohexanamine;platinum(2+);chloride;hydroxide
• CAS: 889100-68-9
• 化学式: C₆H₁₇ClN₂OPt
• 分子量: 363.747
• InChiKey: LJVIRBLRHDJVPX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.74
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  28
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (5'-d(ATGGGTACCCAT)-3')2 、 PtCl(NH3)(cyclohexylamine)(OH) 以 水 为溶剂， 生成 cis-ammine(NH2C6H11)chloro(η1-N7(G7)-d(CGCGTTGTTGCGC))platinum(II)
  参考文献：
  名称：

  Reactions of platinum(II) complexes with a DNA hairpin, d(CGCGTTGTTCGCG): structural characterization and kinetic studies

  摘要：

  Reactions of the platinum complexes cis-[Pt(NH3)(2)Cl(OH2)](+) (1) and cis-[Pt(NH3)(NH2C6H11)Cl(OH2)](+) (2) with a DNA hairpin, d(CGCGTTGTTCGCG) (DNA I), were investigated as a function of pH and ionic strength. The rates of platination were monitored by HPLC. The sites of reactivity for complexes 1 and 2 were determined by chemical probing with dimethylsulfate (DMS), hydrazine, and Fe(EDTA)(2-). The effects of platination on DNA structure and stability were determined by using gel electrophoresis, circular dichroism (CD), and thermal melting. In general, the platinum complexes were most reactive at G7 in the hairpin loop, they caused a destabilization of the DNA hairpin, and they caused a B- to Z-form transition in the DNA conformation. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0020-1693(99)00338-2
• 作为产物：
  描述：

  (氨合)环己基胺二氯铂(II) 在 AgNO₃ 、 NaOH 作用下， 以 水 为溶剂， 生成 PtCl(NH3)(cyclohexylamine)(OH)
  参考文献：
  名称：

  Barton, Sarah J.; Barnham, Kevin J.; Habtemariam, Abraha, Inorganica Chimica Acta, 1998, vol. 273, # 1-2, p. 8 - 13

  摘要：

  DOI：

文献信息

• Barton, Sarah J.; Barnham, Kevin J.; Habtemariam, Abraha, Inorganica Chimica Acta, 1998, vol. 273, # 1-2, p. 8 - 13
  作者：Barton, Sarah J.、Barnham, Kevin J.、Habtemariam, Abraha、Sue, Rodney E.、Sadler, Peter J.

  DOI：——

  日期：——
• Reactions of platinum(II) complexes with a DNA hairpin, d(CGCGTTGTTCGCG): structural characterization and kinetic studies
  作者：May Meroueh、Johan Kjellström、K.S.Margareta Mårtensson、Sofi K.C. Elmroth*、Christine S. Chow*

  DOI：10.1016/s0020-1693(99)00338-2

  日期：2000.1

  Reactions of the platinum complexes cis-[Pt(NH3)(2)Cl(OH2)](+) (1) and cis-[Pt(NH3)(NH2C6H11)Cl(OH2)](+) (2) with a DNA hairpin, d(CGCGTTGTTCGCG) (DNA I), were investigated as a function of pH and ionic strength. The rates of platination were monitored by HPLC. The sites of reactivity for complexes 1 and 2 were determined by chemical probing with dimethylsulfate (DMS), hydrazine, and Fe(EDTA)(2-). The effects of platination on DNA structure and stability were determined by using gel electrophoresis, circular dichroism (CD), and thermal melting. In general, the platinum complexes were most reactive at G7 in the hairpin loop, they caused a destabilization of the DNA hairpin, and they caused a B- to Z-form transition in the DNA conformation. (C) 2000 Elsevier Science S.A. All rights reserved.