(+)-1-(6-fluorobenzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: (+)-1-(6-fluorobenzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride
• 英文别名: 2-[2-(diethylamino)ethoxy]-1-(6-fluoro-1-benzothiophen-5-yl)ethanol;hydrochloride
• 化学式: C₁₆H₂₂FNO₂S*ClH
• 分子量: 347.882
• InChiKey: ZZIBYHMGLVCTCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.85
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(2-chloroethoxy)-1-(6-fluorobenzo[b]thiophen-5-yl)ethanol 生成 (+)-1-(6-fluorobenzo[b]thiophen-5-yl)-2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride
  参考文献：
  名称：

  Agent for potentiating nerve growth factor activity containing

  摘要：

  一种由一般公式\x9bI!表示的1,2-乙二醇衍生物或其盐：##STR1## 具有促进神经生长因子(NFG)活性的效果，并且可用作治疗由中枢神经系统或外周神经系统退化引起的各种疾病，例如老年型阿尔茨海默病、亨廷顿舞蹈症、各种神经病、Riley-Day综合征、创伤性神经损伤、肌萎缩性侧索硬化症（ALS）等。

  公开号：

  US05807887A1

文献信息

• Agent for potentiating nerve growth factor activity containg 1,2-ethanediol derivate or salt thereof
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1223169A1

  公开（公告）日：2002-07-17

  A remedy for diseases caused by degeneration of central nervous system, comprising a 1,2-ethanediol derivative represented by the following general formula or its salt: wherein R1 represents a substituted or unsubstituted phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl or heterocyclic group; R2 represents a hydrogen atom, a C1-6alkyl group or a hydroxyl-protecting group; R3 represents a hydrogen atom or a C1-6alkyl group; nR4's may be the same as or different from one another and each represents a hydrogen atom or a C1-6alkyl group; nR5's may be the same as or different from one another and each represents a hydrogen atom or a C1-6alkyl group; R6 represents a substituted or unsubstituted amino or nitrogen-containing heterocyclic group or an ammonio group; and n represents 0 or an integer of 1 to 6, provided that the following 1,2-ethanediol derivative represented by general formula or its salt: wherein nR1a'S may be the same as or different from one another and each represents a fluorine, chlorine, bromine or iodine atom, C1-6alkyl, C1-6alkoxy or phenyl group; R2a represents a hydrogen atom or a hydroxyl-protecting group; R6a represents a C1-6alkyl-substituted amino group or a pyrrolyl, pyrrolidinyl, piperidyl, piperazinyl, imidazolyl, pyrazolyl, pyridyl, tetrahydropyridyl, pyrimidinyl, morpholinyl, thiomorpholinyl, quinolyl, quinolidinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, quinuclidinyl, thiazolyl, tetrazolyl, thiadiazolyl, pyrrolinyl, imidazolinyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl, purinyl, indazolyl, furyl, thienyl, benzothienyl, pyranyl, isobenzofuranyl, oxazolyl, benzofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, quinoxalyl, dihydroquinoxalinyl, 2,3-dihydrobenzothienyl, 2,3-dihydrobenzopyrrolyl, 2,3-dihydro-4H-1-thianaphthyl, 2,3-dihydrobenzofuranyl, benzo[b]dioxanyl, imidazo[2,3-a]pyridyl, benzo[b]piperazinyl, chromenyl, isothiazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, pyridazinyl, isoindolyl or isoquinolyl group; and n represents an integer of 1 to 5, is excluded.

  一种治疗由中枢神经系统退化引起的疾病的药物，包括以下一般公式或其盐所代表的1,2-乙二醇衍生物：其中R1代表取代或未取代的苯基、萘基、茚基、茚基、四氢萘基或杂环基团；R2代表氢原子、C1-6烷基或羟基保护基团；R3代表氢原子或C1-6烷基；nR4可能相同也可能不同，每个代表氢原子或C1-6烷基；nR5可能相同也可能不同，每个代表氢原子或C1-6烷基；R6代表取代或未取代的氨基或含氮杂环基团或铵基；n代表0或1至6的整数，条件是以下一般公式或其盐所代表的1,2-乙二醇衍生物：其中nR1a'可能相同也可能不同，每个代表氟、氯、溴或碘原子、C1-6烷基、C1-6烷氧基或苯基；R2a代表氢原子或羟基保护基团；R6a代表C1-6烷基取代的氨基团或吡咯基、吡咯啉基、哌啶基、哌嗪基、咪唑基、吡唑基、吡啶基、四氢吡啶基、嘧啶基、吗啉基、硫代嘧啶基、喹啉基、喹啉啉基、四氢喹啉基、四氢异喹啉基、喹啉基、噻唑基、四唑基、噻二唑基、吡咯啉基、咪唑啉基、吡唑啉基、吡咯啉基、吲唑基、呋喃基、噻吩基、苯并噻吩基、吡喃基、异苯并呋喃基、噁唑基、苯并呋喃基、吲哚基、苯并咪唑基、苯并噁唑基、苯并噻嗪基、喹喃基、异吲哚基或异喹啉基团；n代表1至5的整数，被排除。
• POTENTIATOR FOR NERVE GROWTH FACTOR ACTIVITY CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP0790246A1

  公开（公告）日：1997-08-20

  A 1,2-ethanediol derivative represented by the general formula [I] or its salt: has a NGF activity-potentiating effect and is useful as a remedy for various diseases caused by degeneration of central nervous system or peripheral nervous system such as senile dementia of Alzheimer type, Huntington's chorea, various neuropathies, Riley-Day syndrome, traumatic nerve injury, amyotrophic lateral sclerosis (ALS) and the like.

  一种由通式[I]或其盐代表的 1,2-乙二醇衍生物： 具有促进 NGF 活性的作用，可用于治疗中枢神经系统或周围神经系统退化引起的各种疾病，如阿尔茨海默型老年痴呆症、亨廷顿舞蹈症、各种神经病、瑞利-戴伊综合征、创伤性神经损伤、肌萎缩性脊髓侧索硬化症（ALS）等。
• US06034119
  申请人：——

  公开号：——

  公开（公告）日：——
• Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1020427B1

  公开（公告）日：2003-10-01
• US5807887A
  申请人：——

  公开号：US5807887A

  公开（公告）日：1998-09-15