(R)-1-(tert-Butyl-diphenyl-silanyloxy)-trideca-4,7-diyn-6-ol | 342902-96-9

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (R)-1-(tert-Butyl-diphenyl-silanyloxy)-trideca-4,7-diyn-6-ol
• 英文别名: (6R)-1-[tert-butyl(diphenyl)silyl]oxytrideca-4,7-diyn-6-ol
• CAS: 342902-96-9
• 化学式: C₂₉H₃₈O₂Si
• 分子量: 446.705
• InChiKey: COHUQFMWMHPTOU-AREMUKBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.29
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 (R)-1-(tert-Butyl-diphenyl-silanyloxy)-trideca-4,7-diyn-6-ol 在 三乙胺 作用下， 生成 1-(4-O-tert-butyldiphenylsilyl-1-pentynyl)-1(R)-2-octynyl acetate
  参考文献：
  名称：

  Design and synthesis of useful intermediates for novel lipoxygenase substrates through enzymatic resolution

  摘要：

  Unnatural lipoxygenase substrates carrying spacing modifiers with a non-ionic hydroxy terminus and with methylene (flanked by the cis,cis diene moiety) pro-(S)-hydrogen can be synthesized from the intermediates la-lc. These intermediates are conveniently synthesized via enzymatic resolution with lipase in organic solvents. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00495-x
• 作为产物：
  描述：

  2-辛炔-1-醇 在 咪唑 、 正丁基锂 、 草酰氯 、 lipase from Candida rugosa 、 4-甲基苯磺酸吡啶 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 六甲基磷酰三胺 、 乙醚 、 正己烷 、 二氯甲烷 为溶剂， 反应 34.33h， 生成 (R)-1-(tert-Butyl-diphenyl-silanyloxy)-trideca-4,7-diyn-6-ol
  参考文献：
  名称：

  Design and synthesis of useful intermediates for novel lipoxygenase substrates through enzymatic resolution

  摘要：

  Unnatural lipoxygenase substrates carrying spacing modifiers with a non-ionic hydroxy terminus and with methylene (flanked by the cis,cis diene moiety) pro-(S)-hydrogen can be synthesized from the intermediates la-lc. These intermediates are conveniently synthesized via enzymatic resolution with lipase in organic solvents. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(00)00495-x

文献信息

• Design and synthesis of useful intermediates for novel lipoxygenase substrates through enzymatic resolution
  作者：J.S. Yadav、S. Nanda、A.Bhaskar Rao

  DOI：10.1016/s0957-4166(00)00495-x

  日期：2001.2

  Unnatural lipoxygenase substrates carrying spacing modifiers with a non-ionic hydroxy terminus and with methylene (flanked by the cis,cis diene moiety) pro-(S)-hydrogen can be synthesized from the intermediates la-lc. These intermediates are conveniently synthesized via enzymatic resolution with lipase in organic solvents. (C) 2001 Elsevier Science Ltd. All rights reserved.