2-(2-Oxo-1,5-naphthyridin-1-yl)acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(2-Oxo-1,5-naphthyridin-1-yl)acetamide
• 英文别名: 2-(2-oxo-1,5-naphthyridin-1-yl)acetamide
• 化学式: C₁₀H₉N₃O₂
• 分子量: 203.2
• InChiKey: IYHVVSYPBDUGJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  76.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF JUN N-TERMINAL KINASE
  申请人：IMAGO PHARMACEUTICALS, INC.

  公开号：US20170107209A1

  公开（公告）日：2017-04-20

  The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: or a salt or solvate thereof, wherein ring A, C a , C b , Z, R 5 , W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
• TREATMENT OF FIBROTIC DISORDERS WITH JUN N-TERMINAL KINASE INHIBITORS
  申请人：Imago Pharmaceuticals, Inc.

  公开号：US20190231751A1

  公开（公告）日：2019-08-01

  The present disclosure provides a method of treating diseases, conditions or disorders associated with fibrosis in a mammal using inhibitors of the Jun N-terminal kinase (JNK) pathway. The present disclosure in particular provides methods of treating diseases, conditions or disorders associated with fibrosis using a specific class of small molecule JNK inhibitors.
• US9796706B2
  申请人：——

  公开号：US9796706B2

  公开（公告）日：2017-10-24