cis-2,6-diethylpiperazine | 1240618-27-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: cis-2,6-diethylpiperazine
• 英文别名: (2S,6R)-2,6-Diethylpiperazine
• CAS: 1240618-27-2
• 化学式: C₈H₁₈N₂
• 分子量: 142.244
• InChiKey: WOTDHTQZNQMLIS-OCAPTIKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  cis-2,6-diethylpiperazine 、 在 三乙胺 作用下， 生成 (3R,5S)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-3,5-diethylpiperazine-1-carboxamide
  参考文献：
  名称：

  Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

  摘要：

  We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.02.090
• 作为产物：
  描述：

  2,6-二乙基吡嗪 在 platinum(IV) oxide 、 氢气 作用下， 以 溶剂黄146 为溶剂， 生成 cis-2,6-diethylpiperazine
  参考文献：
  名称：

  Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

  摘要：

  We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.02.090

文献信息

• ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS
  申请人：Kalypsys, Inc.

  公开号：EP1735280A1

  公开（公告）日：2006-12-27
• [EN] ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS<br/>[FR] COMPOSES ARYL SULFONAMIDE ET SULFONYL UTILISES COMME MODULATEURS DE PPAR, ET PROCEDES DE TRAITEMENT DE TROUBLES METABOLIQUES
  申请人：KALYPSYS INC

  公开号：WO2005115983A1

  公开（公告）日：2005-12-08

  Aryl sulfonamide and sulfonyl compounds of formula (I) as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
• Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist
  作者：Qingmei Hong、Raman K. Bakshi、Brenda L. Palucki、Min K. Park、Zhixiong Ye、Shuwen He、Patrick G. Pollard、Iyassu K. Sebhat、Jian Liu、Liangqin Guo、Doreen E. Cashen、William J. Martin、David H. Weinberg、Tanya MacNeil、Rui Tang、Constantin Tamvakopoulos、Qianping Peng、Randy R. Miller、Ralph A. Stearns、Howard Y. Chen、Airu S. Chen、Alison M. Strack、Tung M. Fong、D. Euan MacIntyre、Matthew J. Wyvratt、Ravi P. Nargund

  DOI：10.1016/j.bmcl.2011.02.090

  日期：2011.4

  We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models. (C) 2011 Elsevier Ltd. All rights reserved.