[(3R)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octan-3-yl] (2R)-2-hydroxy-2-phenyl-2-thiophen-2-ylacetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: [(3R)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octan-3-yl] (2R)-2-hydroxy-2-phenyl-2-thiophen-2-ylacetate
• 化学式: C27H30NO4S+
• 分子量: 464.6
• InChiKey: DXWPJHCQPLJUKR-SETCOJICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  84
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Quinuclidine derivatives and medicinal compositions containing the same
  申请人：ALMIRALL, S.A.

  公开号：US10588895B2

  公开（公告）日：2020-03-17

  Provided is a method for treating chronic obstructive pulmonary disease or chronic bronchitis, or inhibiting bronchospasm, which method comprises use of a powder inhaler to administer to a human patient in need of such treatment an effective amount of a powder inhalant, wherein the powder inhalant comprises 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide.

  提供了一种治疗慢性阻塞性肺病或慢性支气管炎或抑制支气管痉挛的方法，该方法包括使用粉末吸入器向需要这种治疗的人类患者施用有效量的粉末吸入剂，其中粉末吸入剂包括3(R)-(2-羟基-2,2-二噻吩-2-基乙酰氧基)-1-(3-苯氧基丙基)-1-氮杂双环[2.2.2]辛烷溴化物。
• NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
  申请人：ALMIRALL, S.A.

  公开号：US20190183867A1

  公开（公告）日：2019-06-20

  Provided is a method for treating chronic obstructive pulmonary disease or chronic bronchitis, or inhibiting bronchospasm, which method comprises use of a powder inhaler to administer to a human patient in need of such treatment an effective amount of a powder inhalant, wherein the powder inhalant comprises 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropy1)-1-azoniabicyclo[2.2.2]octane bromide.