1-[4-(1-Adamantyl)-6-methoxy-1,3,5-triazin-2-yl]-3-[2-(trifluoromethyl)phenyl]sulfonylurea

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[4-(1-Adamantyl)-6-methoxy-1,3,5-triazin-2-yl]-3-[2-(trifluoromethyl)phenyl]sulfonylurea
• 化学式: C₂₂H₂₄F₃N₅O₄S
• 分子量: 511.5
• InChiKey: MISSYQVZHPVIOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• ANTIMICROBIAL METHOD BY BLOCKING MANNITOL METABOLISM AND ANTIMICROBIAL COMPOSITION CONTAINING MANNITOL METABOLIC INHIBITOR
  申请人：Research & Business FOUNDATION SUNGKYUNKWAN UNIVERSITY

  公开号：US20150366191A1

  公开（公告）日：2015-12-24

  The present invention relates to an antimicrobial method of killing bacteria having a mannitol metabolic pathway by inhibition of a mannitol metabolism, a method of screening a mannitol metabolic inhibitor, and an antimicrobial composition and cosmetic material containing a mannitol metabolic inhibitor. More particularly, the present invention relates to an antimicrobial method targeted at mannitol dehydrogenase such as mannitol-1-phosphate-5-dehydrogenase (M1PDH), a method of screening an inhibitor, and a composition. Therefore, the antimicrobial method, antimicrobial composition, and cosmetic material which solve a problem of antibiotic resistance and have an excellent antimicrobial effect may be provided.