1,5-Diazocane-3,7-diol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,5-Diazocane-3,7-diol
• 化学式: C₆H₁₄N₂O₂
• 分子量: 146.19
• InChiKey: OUHNIVNXFPHDJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.5
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Process for the production of oxabispidines
  申请人：Pavey John

  公开号：US20050171100A1

  公开（公告）日：2005-08-04

  There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R 1 , R 2 , R 3 , R 4 and R 41 to R 46 have meanings given in the description, which process comprises the dehydrative cyclisaton of a compound of formula II. (II).

  提供了一种制备式I化合物或其药学上可接受的衍生物的过程，其中A、B、G、R1、R2、R3、R4和R41至R46具有描述中给出的含义，该过程包括对式II化合物进行脱水环化反应。 (II)。
• Process for the preparation of oxabispidines
  申请人：——

  公开号：US20040133000A1

  公开（公告）日：2004-07-08

  There is provided a process for the preparation of a benzenesulfonic acid salt of a compound of formula (1) which process comprises reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , A and B have meanings given in the description. 1

  提供一种制备式(1)化合物的苯磺酸盐的过程，该过程包括将式(II)化合物与式(III)化合物反应，其中R1、R2、A和B的含义如说明中所述。
• New process for production of oxabispidines
  申请人：Pavey John

  公开号：US20090036675A1

  公开（公告）日：2009-02-05

  There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R 1 , R 2 , R 3 , R 4 and R 41 to R 46 have meanings given in the description, which process comprises the dehydrative cyclisation of a compound of formula II, (II).

  提供了一种制备I式化合物（I）或其药学上可接受的衍生物的方法，其中A、B、G、R1、R2、R3、R4和R41到R46具有所述描述中给出的含义，该方法包括化合物II（II）的脱水环化。
• New process for the production of oxabispidines
  申请人：Pavey John

  公开号：US20090240051A1

  公开（公告）日：2009-09-24

  There is provided a process for the preparation of a compound of formula I, or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R 1 , R 2 , R 3 , R 4 and R 41 to R 46 have meanings given in the description, which process comprises the dehydrative cyclisation of a compound of formula II,

  提供了一种制备公式I化合物或其药学上可接受的衍生物的方法，其中A、B、G、R1、R2、R3、R4和R41到R46的含义如描述中所给，该方法包括将公式II化合物进行脱水缩环反应。
• New Process For The Preparation Of Oxabispidines
  申请人：Cheema Lal

  公开号：US20070197519A1

  公开（公告）日：2007-08-23

  There is provided a process for the preparation of a compound of formula (I): which process comprises reaction of a compound of formula (TI): with either a compound of formula (ITT): or acrylamide, followed, in the latter case, by reaction of the resulting intermediate of formula (IV): with an alcohol of formula R 2 ═OH and an agent that promotes, or agents that in combination promote, rearrangement and oxidation of the compound of formula IV to an intermediate isocyanate, which may then react with the alcohol of formula R 2 ═OH, and wherein R 1 , R 2 and R 16 have meanings given in the description.

  提供了一种制备化合物(I)的方法，该方法包括将化合物(TI)与化合物(ITT)或丙烯酰胺反应，后者情况下，再将生成的中间体(IV)与具有公式R2═OH的醇和促进化合物IV重排和氧化的试剂或组合试剂反应，所述化合物IV可进一步与公式R2═OH的醇反应，其中R1、R2和R16的含义如描述中所给。