6-(甲基氨基)萘-2-磺酸 | 64375-16-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 6-(甲基氨基)萘-2-磺酸
• 英文名称: 6-methylamino-naphthalene-2-sulfonic acid
• 英文别名: 6-Methylamino-naphthalin-2-sulfonsaeure；N-Methyl-naphthylamin-(2)-sulfonsaeure-(6)；Mansic acid；6-(Methylamino)naphthalene-2-sulphonic acid；6-(methylamino)naphthalene-2-sulfonic acid
• CAS: 64375-16-2
• 化学式: C₁₁H₁₁NO₃S
• 分子量: 237.279
• InChiKey: UEGNVVBWZPHEQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2921199090

反应信息

• 作为反应物：
  描述：

  6-(甲基氨基)萘-2-磺酸 生成 6-(benzoyl-methyl-amino)-naphthalene-2-sulfonyl chloride
  参考文献：
  名称：

  Morgan; Rooke, Journal of the Society of Chemical Industry, 1922, vol. 41, p. 2 T

  摘要：

  DOI：
• 作为产物：
  描述：

  盐酸甲胺 、 2-萘酚-6-磺酸 在 sodium hydroxide 作用下， 生成 6-(甲基氨基)萘-2-磺酸
  参考文献：
  名称：

  Morgan; Rooke, Journal of the Society of Chemical Industry, 1922, vol. 41, p. 2 T

  摘要：

  DOI：

文献信息

• Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif)
  申请人：Morand Francis Eric

  公开号：US20060106102A1

  公开（公告）日：2006-05-18

  Where Y, R 1 -R 8 and R 101 -R 108 are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (1), either alone or as part of a combination therapy.

  本发明提供了式(II)化合物及抑制巨噬细胞迁移抑制因子(MIF)细胞因子或生物活性的方法，其中Y，R1-R8和R101-R108如规范中定义。该方法包括将MIF与式(I)化合物接触。本发明还涉及治疗MIF细胞因子或生物活性所涉及的疾病或病症的方法，包括单独或作为联合治疗的一部分给予式(1)化合物。
• Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same
  申请人：The University of Toledo

  公开号：US10181018B2

  公开（公告）日：2019-01-15

  Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.

  本研究公开了过氧化物酶体增殖物激活受体（PPAR）化合物，以及使用该化合物治疗骨折、治疗骨质疏松症和/或代谢性骨病、诱导骨生成和/或软骨生成的方法。
• Support bound probes and methods of analysis using the same
  申请人：Affymetrix, Inc.

  公开号：US20040038268A1

  公开（公告）日：2004-02-26

  The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.

  本发明提供了对生物大分子（通常是生物聚合物）进行测序、指纹识别和绘图的方法和装置。这些方法利用了多种序列特异性识别试剂，这些试剂也可用于生物样本的分类，并确定其来源的特征。
• Compounds and methods for post incorporation labeling of nucleic acids
  申请人：McGall H. Glenn

  公开号：US20050064479A1

  公开（公告）日：2005-03-24

  Methods are provided for post incorporation labeling of a nucleic acid, including for example cRNA, labeled with nucleotide analogs having a formula selected from the group consisting of wherein A is H or a functional group that permits the attachment of the nucleic acid labeling compound to a nucleic acid; Y and Z are independently H or OH; L is linker group; and P is a connecting group. After incorporation of the nucleic acid (including cRNA) with the above nucleotide analogs, the nucleic acid is labeled with a detectable group reagent wherein said detetable group reagent comprises a chemical moiety which is capable of specifically reacting with said P group to allow coupling of the detectable group to said primed cRNA. Compounds comprising nucleotide analogs are also presented in accordance with the present invention. Methods are also presented for incorporating these compounds into nucleic acids and subsequently labeling the incorporated nucleotide analog with detectable moiety reagent.

  本发明提供了用核苷酸类似物对核酸（包括例如 cRNA）进行掺入后标记的方法，核苷酸类似物的分子式选自由以下组成的组 其中 A 是 H 或允许核酸标记化合物附着到核酸上的官能团；Y 和 Z 独立地是 H 或 OH；L 是连接基团；P 是连接基团。在核酸（包括 cRNA）与上述核苷酸类似物结合后，用可检测基团试剂标记核酸，其中所述可检测基团试剂包括能与所述 P 基团发生特异性反应的化学分子，以便将可检测基团与所述引物 cRNA 偶联。根据本发明还提出了包含核苷酸类似物的化合物。还介绍了将这些化合物掺入核酸并随后用可检测的分子试剂标记掺入的核苷酸类似物的方法。
• Polymer arrays
  申请人：Pirrung C. Michael

  公开号：US20050118706A1

  公开（公告）日：2005-06-02

  The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.

  本发明提供了对生物大分子（通常是生物聚合物）进行测序、指纹识别和绘图的方法和装置。这些方法利用了多种序列特异性识别试剂，这些试剂也可用于生物样本的分类，并确定其来源的特征。