N-ethyl-2,2,4,4-tetramethylhexan-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethyl-2,2,4,4-tetramethylhexan-1-amine
• 化学式: C₁₂H₂₇N
• 分子量: 185.35
• InChiKey: ROFCYIUILVYRFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• O/W TYPE EMULSION
  申请人：NOF CORPORATION

  公开号：US20190110986A1

  公开（公告）日：2019-04-18

  The present invention provides an O/W type emulsion having a volume median diameter of not more than 100 nm and containing a compound represented by the formula (1) wherein X a and X b are each independently X 1 , X 2 or a 1,4-piperazinediyl group; s is 1 or 2, R 4 is an alkyl group having 1-6 carbon atoms, n a and n b are each independently 0 or 1, R 1a , R 1b , R 2a and R 2b are each independently an alkylene group having 1-6 carbon atoms, Y a and Y b are each independently an ester bond, or the like, and R 3a and R 3b are each independently a liposoluble vitamin residue or the like.

  本发明提供了一种体积中值直径不超过100纳米的O/W型乳液，其含有由式（1）表示的化合物， 其中X a 和X b 分别独立地为X 1 、X 2 或1,4-哌嗪二基基团； s为1或2， R 4 为具有1-6个碳原子的烷基基团， n a 和n b 分别独立地为0或1， R 1a 、R 1b 、R 2a 和R 2b 分别独立地为具有1-6个碳原子的烷基基团， Y a 和Y b 分别独立地为酯键，或类似物，以及 R 3a 和R 3b 分别独立地为脂溶性维生素残基或类似物。
• NON-CLEAVABLE POLYMER CONJUGATED WITH ALPHA V BETA 3 INTEGRIN THYROID ANTAGONISTS
  申请人：NANOPHARMACEUTICALS, LLC

  公开号：US20170348425A1

  公开（公告）日：2017-12-07

  Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward and classified as anti-angiogenic thyrointegrin antagonists, which may be capable of reacting with one or more cell surface receptors of the integrin αvβ3 receptor family. Anti-angiogenic thyrointegrin antagonists or derivatives thereof are conjugated via a non-cleavable linker having an amine, diamine or triazole linkage to polymers of Polyethylene Glycol, cyclodextrin, chitosan, alginic acid or hyaluronic acid, forming a single chemical entity. Utility of the compositions disclosed may treat angiogenesis-mediated disorders such as Cancer (Solid tumors and Liquid tumors), ocular disorders (Diabetic Retinopathy and Age-related Macular Degeneration), inflammatory disorders (arthritis, osteoarthritis), atherosclerosis, lesions, and dermatology (Rosacea, Psoriasis, skin cancer) and diseases mediated or dependent upon the generation of new blood cells via angiogenesis to persist and the treatment thereof or dependent on antagonizing the formation of new blood vessels to slow or eliminate angiogenic pathways.

  化学成分及其合成方法。本文所披露和描述的化合物是针对和分类为抗血管生成的甲状腺整合素拮抗剂，可能能够与整合素αvβ3受体家族的一个或多个细胞表面受体发生反应。抗血管生成的甲状腺整合素拮抗剂或其衍生物通过非可切割的连接剂（具有胺、二胺或三唑键）与聚合物聚乙二醇、环糊精、壳聚糖、海藻酸或透明质酸结合，形成单一的化学实体。所披露的化合物可用于治疗血管生成介导的疾病，如癌症（实体肿瘤和液体肿瘤）、眼部疾病（糖尿病视网膜病变和年龄相关性黄斑变性）、炎症性疾病（关节炎、骨关节炎）、动脉粥样硬化、损伤和皮肤科疾病（酒渣鼻、银屑病、皮肤癌）以及通过血管生成产生新血细胞以维持和治疗相关的疾病，或通过拮抗新血管形成来减缓或消除血管生成途径。
• O/W type emulsion
  申请人：NOF CORPORATION

  公开号：US11395798B2

  公开（公告）日：2022-07-26

  The present invention provides an O/W type emulsion having a volume median diameter of not more than 100 nm and containing a compound represented by the formula (1) wherein Xa and Xb are each independently X1, X2 or a 1,4-piperazinediyl group; s is 1 or 2, R4 is an alkyl group having 1-6 carbon atoms, na and nb are each independently 0 or 1, R1a, R1b, R2a and R2b are each independently an alkylene group having 1-6 carbon atoms, Ya and Yb are each independently an ester bond, or the like, and R3a and R3b are each independently a liposoluble vitamin residue or the like.

  本发明提供了一种体积中值直径不超过 100 纳米的 O/W 型乳液，其中含有一种由式（1）表示的化合物 其中 Xa 和 Xb 各自独立地为 X1、X2 或 1,4-哌嗪二基； s 为 1 或 2、 R4 是具有 1-6 个碳原子的烷基、 na 和 nb 分别独立地为 0 或 1、 R1a、R1b、R2a 和 R2b 各自独立地为具有 1-6 个碳原子的亚烷基、 Ya 和 Yb 各自独立地为酯键或类似键，以及 R3a 和 R3b 各自独立地为脂溶性维生素残基或类似物。
• US9708628B2
  申请人：——

  公开号：US9708628B2

  公开（公告）日：2017-07-18