5,9,13,20-Tetramethyl-1,3,7,11,15,18,22-heptazabicyclo[7.7.7]tricosane

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5,9,13,20-Tetramethyl-1,3,7,11,15,18,22-heptazabicyclo[7.7.7]tricosane
• 英文别名: 5,9,13,20-tetramethyl-1,3,7,11,15,18,22-heptazabicyclo[7.7.7]tricosane
• 化学式: C₂₀H₄₅N₇
• 分子量: 383.6
• InChiKey: XVRBZEATWKXJDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  75.4
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS
  申请人：The University of Melbourne

  公开号：EP3098225A1

  公开（公告）日：2016-11-30

  The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.

  本发明涉及可用作金属配体、含有分子识别基团或可与分子识别基团结合的化合物以及制造这些化合物的方法。一旦含有分子识别基团的化合物与合适的金属放射性核素配位，配位后的化合物就可用作放射治疗和诊断成像领域的放射性药物。因此，本发明还涉及利用本发明的放射性标记化合物进行诊断和治疗的方法。
• FUNCTIONALISATION OF CAGE AMINE LIGANDS FOR METALLO-RADIOPHARMACEUTICALS
  申请人：The University of Melbourne

  公开号：EP2788354B1

  公开（公告）日：2016-11-30
• CAGE AMINE LIGANDS FOR METALLO-RADIOPHARMACEUTICALS
  申请人：The University of Melbourne

  公开号：US20160354497A1

  公开（公告）日：2016-12-08

  The present invention relates to compounds that are useful as metal ligands and which can be bound to a biological entity such as a molecular recognition moiety and methods of making these compounds. Once the compounds that are bound to a biological entity are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.
• US9364570B2
  申请人：——

  公开号：US9364570B2

  公开（公告）日：2016-06-14