2-[4-(2-Chloro-ethyl)-piperazin-1-yl]-ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(2-Chloro-ethyl)-piperazin-1-yl]-ethanol
• 英文别名: 2-[4-(2-Chloroethyl)piperazin-1-yl]ethanol
• 化学式: C₈H₁₇ClN₂O
• mdl: MFCD04116878
• 分子量: 192.689
• InChiKey: PYEXDMFOTUECFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  T406石油添加剂 、 2-[4-(2-Chloro-ethyl)-piperazin-1-yl]-ethanol 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 生成 2-[4-(2-Benzotriazol-2-yl-ethyl)-piperazin-1-yl]-ethanol 、 2-[4-(2-Benzotriazol-1-yl-ethyl)-piperazin-1-yl]-ethanol
  参考文献：
  名称：

  Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone

  摘要：

  This paper outlines the synthesis and the pharmacological screening of a series of novel 1- and 2-[2-[4-(X)-1-piperazinyl]ethyl]benzotriazoles and 1-[3-[4-(X)-1-piperazinyl]propoxy]benzotriazoles, which are structurally related to trazodone. Anti serotonergic, antiadrenergic and antihistaminic in vitro activity and in vivo analgesic action are described. Some of the investigated compounds show overall pharmacological profiles similar to that of the antidepressant trazodone.

  DOI：

  10.1016/0223-5234(96)88212-2
• 作为产物：
  描述：

  N-羟乙基哌嗪 、 1-溴-2-氯乙烷 以 甲苯 为溶剂， 生成 2-[4-(2-Chloro-ethyl)-piperazin-1-yl]-ethanol 、 2-(4-{2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-ethyl}-piperazin-1-yl)-ethanol
  参考文献：
  名称：

  Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone

  摘要：

  This paper outlines the synthesis and the pharmacological screening of a series of novel 1- and 2-[2-[4-(X)-1-piperazinyl]ethyl]benzotriazoles and 1-[3-[4-(X)-1-piperazinyl]propoxy]benzotriazoles, which are structurally related to trazodone. Anti serotonergic, antiadrenergic and antihistaminic in vitro activity and in vivo analgesic action are described. Some of the investigated compounds show overall pharmacological profiles similar to that of the antidepressant trazodone.

  DOI：

  10.1016/0223-5234(96)88212-2

文献信息

• US3985878A
  申请人：——

  公开号：US3985878A

  公开（公告）日：1976-10-12
• Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone
  作者：G Caliendo、R Di Carlo、G Greco、R Meli、E Novellino、E Perissutti、V Santagada

  DOI：10.1016/0223-5234(96)88212-2

  日期：1995.1

  This paper outlines the synthesis and the pharmacological screening of a series of novel 1- and 2-[2-[4-(X)-1-piperazinyl]ethyl]benzotriazoles and 1-[3-[4-(X)-1-piperazinyl]propoxy]benzotriazoles, which are structurally related to trazodone. Anti serotonergic, antiadrenergic and antihistaminic in vitro activity and in vivo analgesic action are described. Some of the investigated compounds show overall pharmacological profiles similar to that of the antidepressant trazodone.