8-(cyclopentylmethyl)-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-7H-imidazo[1,2-a]pyrazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡嗪类
• 英文名称: 8-(cyclopentylmethyl)-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-7H-imidazo[1,2-a]pyrazin-3-one
• 化学式: C₂₅H₂₅N₃O₃
• 分子量: 415.5
• InChiKey: ZHUQRWXCVVZBSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  85.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Chemiluminescent wetness indicator for absorbent products
  申请人：INTERNATIONAL PAPER COMPANY

  公开号：US10273463B2

  公开（公告）日：2019-04-30

  Disclosed herein are fluff pulp compositions, absorbent articles comprising the fluff pulp compositions, and related methods. The fluff pulp compositions comprise a chemiluminescent system configured to produce visible light upon contact with an aqueous system. Representative absorbent articles include disposable diapers and adult incontinence products. Representative chemiluminescent systems include bioluminescent systems.

  本文公开了绒毛浆组合物、包含绒毛浆组合物的吸水物品以及相关方法。绒毛浆组合物包含一个化学发光系统，该系统与水性系统接触后可产生可见光。具有代表性的吸收物品包括一次性尿布和成人失禁用品。具有代表性的化学发光系统包括生物发光系统。
• Synthesis of coelenterazine
  申请人：International Paper Company

  公开号：US11008326B2

  公开（公告）日：2021-05-18

  Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.

  本文公开了腔肠素的合成方法。还公开了包括腔肠素和腔肠素衍生物的物品。具有代表性的吸收物品包括一次性尿布和成人失禁用品。
• Full length kinase activity-conformation reporter
  申请人：UNIVERSITAT INNSBRUCK

  公开号：US11237173B2

  公开（公告）日：2022-02-01

  The present invention provides a reporter for a protein fragment complementation assay characterized in that the reporter is a fused protein comprising a first fragment, a second fragment and a protein kinase sequence section, wherein the first fragment and the second fragment are derived from different sections of the same split protein, and wherein the protein kinase sequence section intervenes between the first fragment and the second fragment and wherein the kinase sequence section comprises a kinase domain sequence and one or more regulatory sequence(s). Further the invention provides polynucleotides and cells encoding for the reporter as well as methods of conducting a protein fragment complementation assay with the reporter according to the invention.

  本发明提供了一种用于蛋白质片段互补检测的报告基因，其特征在于该报告基因是一种融合蛋白，包括第一片段、第二片段和蛋白质激酶序列部分，其中第一片段和第二片段来自同一分裂蛋白的不同部分，蛋白质激酶序列部分介于第一片段和第二片段之间，其中激酶序列部分包括激酶结构域序列和一个或多个调控序列。此外，本发明还提供了编码报告基因的多核苷酸和细胞，以及用本发明报告基因进行蛋白质片段互补检测的方法。
• FULL LENGTH KINASE ACTIVITY-CONFORMATION REPORTER
  申请人：Universität Innsbruck

  公开号：EP3519830A1

  公开（公告）日：2019-08-07
• SECRETED LUCIFERASE MLUC7 AND USE THEREOF
  申请人：Golz Stefan

  公开号：US20100105090A1

  公开（公告）日：2010-04-29

  The invention relates to the nucleotide and amino acid sequences and to the activity and use of the secreted MLuc7 luciferase.