2-aminocyclohexanethiol | 23583-25-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-aminocyclohexanethiol
• 英文别名: 2-Amino-cyclohexan-thiol；2-aminocyclohexane-1-thiol
• CAS: 23583-25-7
• 化学式: C₆H₁₃NS
• mdl: MFCD19206491
• 分子量: 131.242
• InChiKey: BYCQYUBCJFOYRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] DIMERIC COMPOUNDS OF PIPERIDINE, PIPERAZINE OR MORPHOLINE OR THEIR 7-MEMBERED ANALOGS SUITABALE FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS<br/>[FR] COMPOSES DIMERES DE PIPERIDINE, PIPERAZINE OU MORPHOLINE OU LEURS PRODUITS ANALOGUES A 7 ELEMENTS, DESTINES AU TRAITEMENT DE MALADIES NEURODEGENERATIVES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2006008259A1

  公开（公告）日：2006-01-26

  Formula (I’’), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof.

  公式(I'')，N-氧化物形式，药用可接受的增加盐和它们的立体化学异构形式。
• WATER-SOLUBLE AZO COMPOUND OR SALT THEREOF, INK AND RECORDING MEDIUM
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：US20210292566A1

  公开（公告）日：2021-09-23

  A compound represented by formula (1) or a salt thereof, and an ink including the same. In formula (1), each Q independently represents a halogen atom; R 11 and R 12 independently represent an alkyl group substituted by an ionic hydrophilic group; and A 1 represents a C1-C3 alkoxy-substituted alkylamino group

  由式（1）表示的化合物或其盐，以及包含该化合物的墨水。在式（1）中，每个Q独立表示卤素原子；R11和R12分别表示被离子亲水基团取代的烷基基团；A1表示C1-C3烷氧基取代的烷基氨基基团。
• COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION
  申请人：Cleave Biosciences, Inc.

  公开号：US20140235548A1

  公开（公告）日：2014-08-21

  Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed. The compounds and compositions inhibit the enzymatic activity of a JAMM domain, including the JAMM domain of the CSN5 subunit of the COP9-signalsome (CSN), the JAMM domain of the Rpn11/Poh1/Psmd14 subunit of the 26S proteasome, the JAMM domain of AMSH, the JAMM domain of AMSH-LP, the JAMM domain of BRCC36, among other JAMM domains.

  本文介绍了化合物、药物组合物以及使用这些化合物治疗或预防与JAMM蛋白相关或介导的疾病或障碍的方法。这些化合物和组合物抑制JAMM域的酶活性，包括COP9信号体（CSN）的CSN5亚基的JAMM域、26S蛋白酶的Rpn11/Poh1/Psmd14亚基的JAMM域、AMSH的JAMM域、AMSH-LP的JAMM域、BRCC36的JAMM域等其他JAMM域。
• Amidothiol derivatives
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0021637A1

  公开（公告）日：1981-01-07

  Amidothiol derivatives have the formula wherein: R represents an alkyl, alk-2 to 6 - enyl, phenylalkyl, phenyl or heterocyclic group optionally substituted by one or more functional groups inert to electrochemical oxidation: R1, R2, R3 and R4 independently represent hydrogen or substituent groups, and r5 represents alkyl, phenylalkyl or phenyl. The derivatives are useful in the preparation of pharmaceutically active compounds and dyestuffs and have herbicidal and/or antibacterial activity. The compounds can be prepared by electrochemical oxidation of a corresponding organic disulphide in the presence of the corresponding alkene and the corresponding organic nitrite, and treatment of the reaction product with water.

  酰胺硫醇衍生物的化学式为 其中 R 代表烷基、烷-2-6-烯基、苯基烷基、苯基或杂环基团，可任选被一个或多个电化学氧化惰性官能团取代： R1、R2、R3 和 R4 分别代表氢或取代基，r5 代表烷基、苯基烷基或苯基。这些衍生物可用于制备医药活性化合物和染料，并具有除草和/或抗菌活性。这些化合物的制备方法是：在相应的烯烃和相应的有机亚硝酸盐存在下，对相应的有机二硫化物进行电化学氧化，然后用水处理反应产物。
• A process for electrochemical additions to alkenes
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0022614A1

  公开（公告）日：1981-01-21

  Organic compounds having vicinal functional groups, such as amidothioethers and esterthioethers, are prepared by electrochemically oxidizing an organic disulphide, an organic diselenide, a hexasubstituted organic disilane or a tretrasubstituted organic hydrazine in the presence of an alkene and an organic nucleophile.

  在烯烃和有机亲核剂的存在下，通过电化学氧化有机二硫化物、有机二硒化物、六取代有机二硅烷或三取代有机肼，可制备出具有邻接官能团的有机化合物，如脒硫醚和酯硫醚。