(E)-(4S,6S,9R)-6-(tert-Butyl-dimethyl-silanyloxy)-4,10,10-trimethoxy-3,9-dimethyl-dec-2-en-1-ol | 143236-73-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (E)-(4S,6S,9R)-6-(tert-Butyl-dimethyl-silanyloxy)-4,10,10-trimethoxy-3,9-dimethyl-dec-2-en-1-ol
• 英文别名: (E,4S,6S,9R)-6-[tert-butyl(dimethyl)silyl]oxy-4,10,10-trimethoxy-3,9-dimethyldec-2-en-1-ol
• CAS: 143236-73-1
• 化学式: C₂₁H₄₄O₅Si
• 分子量: 404.663
• InChiKey: HUAQELQTKHJASM-BBFGAQQPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.76
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E)-(4S,6S,9R)-6-(tert-Butyl-dimethyl-silanyloxy)-4,10,10-trimethoxy-3,9-dimethyl-dec-2-en-1-ol 在 barium permanganate 、 Celite 作用下， 以 二氯甲烷 为溶剂， 生成 (E)-(4S,6S,9R)-6-(tert-Butyl-dimethyl-silanyloxy)-4,10,10-trimethoxy-3,9-dimethyl-dec-2-enal
  参考文献：
  名称：

  Synthetic investigations of rapamycin. 1. Synthesis of a C10-C21 fragment

  摘要：

  Phosphine oxide 2, representing the C-10-C21 portion of rapamycin, was stereoselectively synthesized and was demonstrated to undergo a Homer-Wittig reaction to form triene 25 as an 8:1 mixture of trans-cis isomers.

  DOI：

  10.1021/jo00045a007
• 作为产物：
  描述：

  2-[(E)-(1R,4S,6S)-4,9-Bis-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-1,7-dimethyl-non-7-enyl]-[1,3]dithiolane 在 吡啶 、 氟化氢吡啶 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 四氢呋喃 为溶剂， 生成 (E)-(4S,6S,9R)-6-(tert-Butyl-dimethyl-silanyloxy)-4,10,10-trimethoxy-3,9-dimethyl-dec-2-en-1-ol
  参考文献：
  名称：

  Synthetic investigations of rapamycin. 1. Synthesis of a C10-C21 fragment

  摘要：

  Phosphine oxide 2, representing the C-10-C21 portion of rapamycin, was stereoselectively synthesized and was demonstrated to undergo a Homer-Wittig reaction to form triene 25 as an 8:1 mixture of trans-cis isomers.

  DOI：

  10.1021/jo00045a007

文献信息

• Synthetic investigations of rapamycin. 1. Synthesis of a C10-C21 fragment
  作者：Stephanie D. Meyer、Tetsuo Miwa、Masashi Nakatsuka、Stuart L. Schreiber

  DOI：10.1021/jo00045a007

  日期：1992.9

  Phosphine oxide 2, representing the C-10-C21 portion of rapamycin, was stereoselectively synthesized and was demonstrated to undergo a Homer-Wittig reaction to form triene 25 as an 8:1 mixture of trans-cis isomers.