N-Methylbutane-1,4-diamine, Dihydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-Methylbutane-1,4-diamine, Dihydrochloride
• 英文别名: 4-azaniumylbutyl(methyl)azanium;dichloride
• 化学式: C5H16Cl2N2
• 分子量: 175.1
• InChiKey: XZQGIPYFXROFMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.79
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  4
• 氢受体数：
  2

文献信息

• Enhanced production of taxanes by cell cultures of taxus species
  申请人：Phyton Inc.

  公开号：EP1398384A1

  公开（公告）日：2004-03-17

  This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g. brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e. media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T. chinensis is particularly enhanced by use of one or more of these conditions, yield of taxanes for all Taxus species has been found to benefit from use of these conditions.

  本发明提供了可从所有已知的紫杉品种（如brevifolia、canadensis、cuspidata、baccata、globosa、floridana、wallichiana、media和chinensis）中以极高产率生产紫杉醇、巴卡丁Ⅲ和其他紫杉醇类化合物或紫杉素的方法。已发现对培养条件（即培养基成分和操作模式）的特定修改可提高所有紫杉属植物细胞培养中各种紫杉素的产量。特别优选的增强剂包括银离子或银离子络合物、茉莉酸（尤其是甲酯）、与辅助素相关的生长调节剂和苯丙醇途径抑制剂，如 3,4-亚甲二氧基-6-硝基肉桂酸。这些增产剂可以单独使用，也可以相互结合或在其他增产条件下使用。虽然使用其中一种或多种条件可特别提高植物细胞培养 T. chinensis 的紫杉醇产量，但已发现使用这些条件可提高所有紫杉属植物的紫杉醇产量。
• Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures
  申请人：Phyton Holdings, LLC

  公开号：US10172306B2

  公开（公告）日：2019-01-08

  The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives.

  本发明涉及一种生产缩二烯醇、缩二烯醇酯和/或 Tiglian-3-one 衍生物的方法，该方法包括以下步骤：(a) 在营养培养基中以悬浮细胞培养法培养选自大戟科植物的植物细胞，其中细胞产生茵酚、一种或多种茵酚酯和/或一种或多种Tiglian-3-酮衍生物；以及 (b) 回收(a)中产生的茵酚、一种或多种茵酚酯和/或一种或多种Tiglian-3-酮衍生物。本发明还涉及一种植物悬浮细胞培养物，其中细胞来自选自大戟科的植物，植物细胞产生茵酚和/或一种或多种茵酚酯和/或一种或多种惕各-3-酮衍生物。
• ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF TAXUS SPECIES
  申请人：PHYTON, INC.

  公开号：EP0954596B1

  公开（公告）日：2006-01-04
• PRODUCTION OF INGENOL, INGENOL ESTERS AND/OR TIGLIAN-3-ONE DERIVATIVES BY EUPHORBIACEAE PLANT CELL SUSPENSION CULTURES
  申请人：Phyton Holdings, LLC

  公开号：EP3270686A1

  公开（公告）日：2018-01-24
• ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF TAXUS SPECIES
  申请人：Bringi Venkataraman

  公开号：US20080108115A1

  公开（公告）日：2008-05-08

  This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T. chinensis is particularly enhanced by use of one or more of these conditions, yield of taxanes for all Taxus species has been found to benefit from use of these conditions.