[(2S)-3-chloro-2-hydroxypropyl]-trimethylazanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [(2S)-3-chloro-2-hydroxypropyl]-trimethylazanium
• 化学式: C6H15ClNO+
• 分子量: 152.64
• InChiKey: XIUCEANTZSXBQQ-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  盐酸 、 三氯化锑 、 [(2S)-3-chloro-2-hydroxypropyl]-trimethylazanium 以 水 为溶剂， 生成
  参考文献：
  名称：

  Homochirality to design high-T_c lead-free ferroelastic semiconductors

  摘要：

  High-T_c lead-free ferroelastic semiconductor (R/S-CTA)₂SbCl₅ was obtained through an H/OH-substitution-induced homochirality strategy, and undergoes phase transition at 410 K accompanied by switching between the SHG-active and SHG-inactive states.

  DOI：

  10.1039/d4tc00428k

文献信息

• PREPARATION METHOD OF HIGH-PURITY L-CARNITINE
  申请人：Gu Shuhua

  公开号：US20110263897A1

  公开（公告）日：2011-10-27

  The present invention relate to a preparation method of high-purity L-carnitine which belongs to an important technique of quality control in different steps of chiral medicine production. The method comprises the following steps of: monitoring the content of the L-isomer impurity in chiral material S-epichlorohydrin by gas chromatography and chiral column and controlling the content of the L-isomer impurity in chiral raw material in the definite range; monitoring and controlling the specific optical rotation of the chiral intermediate L-3-chloro-2-hydroxy-N,N,N-trimethyl-propanaminium in the definite ranges using a polarimeter; monitoring the content of the R-isomer in the intermediate L-3-cyano-2-hydroxy-N,N,N-trimethyl-propanaminium using derivation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC and controlling the content of the isomer in the intermediate in the definite range; and measuring the final product L-carnitine using derviation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC. This method gives the high-purity L-carnitine in which the content of L-isomer may be more than 97% and that of R-isomerless than 2%.

  本发明涉及高纯度L-肉碱的制备方法，属于手性药物生产不同步骤的质量控制的重要技术。该方法包括以下步骤：通过气相色谱和手性柱监测手性原料S-环氧氯丙烷中L-异构体杂质的含量，并控制手性原料中L-异构体杂质的含量在一定范围内；使用旋光仪监测和控制手性中间体L-3-氯-2-羟基-N，N，N-三甲基丙胺在一定范围内的比旋光度；通过HPLC使用衍生剂（+）α-甲基-6-甲氧基-2-萘乙酰氯监测中间体L-3-氰-2-羟基-N，N，N-三甲基丙胺中R-异构体的含量，并控制中间体中异构体的含量在一定范围内；通过HPLC使用衍生剂（+）α-甲基-6-甲氧基-2-萘乙酰氯测量最终产品L-肉碱。该方法可得到高纯度的L-肉碱，其中L-异构体的含量可达97%以上，R-异构体的含量小于2%。
• A PREPARATION METHOD OF HIGH-PURITY L-CARNITINE
  申请人：Changzhou Multiple Dimension Institute Of Industry Technology Co., Ltd.

  公开号：EP2360141A1

  公开（公告）日：2011-08-24

  The present invention relate to a preparation method of high-purity L-carnitine which belongs to an important technique of qulity control in different steps of chiral medicine production. The method comprises the following steps of :monitoring the content of the L-isomer impurity in chiral material S-epichlorohydrin by gas chromatography and chiral cilumn and controlling the content of the L-isomer impurity in chiral raw material in the definite range; monitoring and controlling the specific optical rotation of the chiral intermediate L-3-chloro-2-hydroxy-N,N,N-trimethyl-propanaminium in the definite ranges using a polarimeter; monitoring the content of the R-isomer in the intermediate L-3-cyano-2-hydroxy-N,N,N-trimethyl-propanaminium using derivation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC and controlling the content of the isomer in the intermediate in the definite range; and measuring the final product L-carnitine using derviation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC. This method gives the high-purity L-carnitine in which the content of L-isomer may be more than 97% and that of R-isomer less than 2%.

  本发明涉及一种高纯度左旋肉碱的制备方法，属于手性药物生产不同步骤中质量控制的一项重要技术。该方法包括以下步骤用气相色谱法和手性色谱柱监测手性原料 S-环氧氯丙烷中 L-异构体杂质的含量，并控制手性原料中 L-异构体杂质的含量在一定范围内；用旋光仪监测和控制手性中间体 L-3-氯-2-羟基-N,N,N-三甲基丙铵的比旋光度在一定范围内；使用衍生剂(+)α-甲基-6-甲氧基-2-萘甲酰氯，通过高效液相色谱法监测中间体 L-3-氰基-2-羟基-N,N,N-三甲基丙铵中 R 异构体的含量，并控制中间体中异构体的含量在一定范围内；使用衍生剂(+)α-甲基-6-甲氧基-2-萘甲酰氯，通过高效液相色谱法测量最终产物 L-肉碱。这种方法可以得到高纯度的左旋肉碱，其中左旋异构体的含量可超过 97%，R-异构体的含量低于 2%。
• US4814506A
  申请人：——

  公开号：US4814506A

  公开（公告）日：1989-03-21
• US9096493B2
  申请人：——

  公开号：US9096493B2

  公开（公告）日：2015-08-04