N'-ethenyl-3-methylbutanimidamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-ethenyl-3-methylbutanimidamide
• 化学式: C₇H₁₄N₂
• 分子量: 126.2
• InChiKey: XRROENHQIGAMBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS<br/>[FR] PYRROLOPYRIDINES SUBSTITUÉES EN TANT QU'INHIBITEURS DE JAK
  申请人：ACLARIS THERAPEUTICS INC

  公开号：WO2020223728A1

  公开（公告）日：2020-11-05

  The present invention relates to new pyrrolopyridine compounds having the structures of Formula (I)-(IV), wherein the R groups, A, B, C, D and n are as defined in the detailed description, and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

  本发明涉及具有化学式（I）-（IV）结构的新吡咯吡啶化合物，其中R基团，A、B、C、D和n的定义如详细说明中所述，以及这些化合物及其应用作为治疗疾病的药物。还提供了用于治疗疾病如瘙痒症、脱发、雄激素性脱发、斑秃、白癜风和牛皮癣的方法，用于抑制人类或动物主体中JAK激酶活性。
• [EN] POLYAMINE SULFONAMIDES AND USES THEREOF<br/>[FR] SULFONAMIDES DE POLYAMINE ET LEURS UTILISATIONS
  申请人：UNIV FLORIDA

  公开号：WO2017079609A1

  公开（公告）日：2017-05-11

  Cancer is a disease for which there remains a great unmet medical need, and therefore the discovery and development of new antineoplastic agents is critically important. The present invention relates in part to new therapeutic compounds with antineoplastic activity. Provided herein are polyamine sulfonamides such as compounds of Formula (I), or pharmaceutically acceptable salts thereof, which may be used in the treatment and/or prevention of diseases such as cancer. Also provided herein are pharmaceutical compositions and kits comprising the inventive compounds. Furthermore, the present invention provides methods of treating and/or preventing diseases (e.g., cancer) using compounds of Formula (I), or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof. Other methods provided include methods for inducing apoptosis of a cell, as well as methods for inhibiting alpha-enolase enzymatic activity in vivo and in vitro.

  癌症是一种存在着巨大未满足医疗需求的疾病，因此发现和开发新的抗肿瘤药物至关重要。本发明部分涉及具有抗肿瘤活性的新治疗化合物。在此提供的是聚胺磺酰胺，如式（I）化合物或其药学上可接受的盐，可用于治疗和/或预防癌症等疾病。此外，在此提供了包括这些创新化合物的药物组合物和套装。此外，本发明提供了使用式（I）化合物或其药学上可接受的盐，或其药物组合物治疗和/或预防疾病（例如癌症）的方法。另外提供的方法包括诱导细胞凋亡的方法，以及在体内和体外抑制α-烯醇酶酶活性的方法。