N-benzyl-3-chloro-N-[cyano-(3,4,5-trimethoxyphenyl)methyl]-1-benzothiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: N-benzyl-3-chloro-N-[cyano-(3,4,5-trimethoxyphenyl)methyl]-1-benzothiophene-2-carboxamide
• 化学式: C₂₇H₂₃ClN₂O₄S
• 分子量: 507.0
• InChiKey: IUQCRPMOGXDXRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors
  申请人：Kitamura Toshio

  公开号：US20090280483A1

  公开（公告）日：2009-11-12

  The present invention provides methods for screening compounds which inhibit activation of a member of the IL-6 signaling pathways, comprising: (a) a positive screening step using a cell capable of being killed by IL-6 stimulation to select compounds which inhibit death of the cell when it is stimulated by IL-6; and then (b) a biochemical screening step to further select compounds which inhibit activation of a member of the IL-6 signaling pathways by a biochemical means from the compounds selected in step (a). The present invention also provides compounds which inhibit activation of a member of the IL-6 signaling pathways identified using said methods.