2-nitro-3H-quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-nitro-3H-quinazolin-4-one
• 化学式: C8H5N3O3
• 分子量: 191.14
• InChiKey: YCCOVPITJFGBLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Alkyne substituted quinazoline compound and methods of use
  申请人：Newgen Therapeutics, Inc.

  公开号：US11524956B2

  公开（公告）日：2022-12-13

  The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).

  本发明提供了烷基取代的喹唑啉化合物，如式（I）化合物，它们是不可逆的 ErbB 激酶抑制剂。这些化合物可用于治疗与 ErbB 激酶活性有关的疾病和失调，如过度增殖性失调（如癌症）。
• ALKYNE SUBSTITUTED QUINAZOLINE COMPOUND AND METHODS OF USE
  申请人：Newgen Therapeutics, Inc.

  公开号：US20210047303A1

  公开（公告）日：2021-02-18

  The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer).