5-Chloro-2-(3,4-dichlorophenyl)-7-(trifluoromethyl)quinoxaline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-Chloro-2-(3,4-dichlorophenyl)-7-(trifluoromethyl)quinoxaline
• 化学式: C₁₅H₆Cl₃F₃N₂
• 分子量: 377.6
• InChiKey: WOGGGGGHQZXITR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 2-Phenylquinoxalines as inhibitors for MPP1
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

  公开号：EP1683523A1

  公开（公告）日：2006-07-26

  The present invention relates to 2-phenylquinoxaline derivatives as well as pharmaceutical compositions containing at least one of these 2-phenylquinoxaline derivatives together with pharmaceutically acceptable carrier, excipient and/or diluents. Said 2-phenylquinoxaline derivatives have been identified as specific inhibitors of the mitotic kinesin MPP1, and are useful for the treatment of cancers and proliferative diseases including tumor growth and metastases.

  本发明涉及 2-苯基喹喔啉衍生物以及含有至少一种 2-苯基喹喔啉衍生物和药学上可接受的载体、赋形剂和/或稀释剂的药物组合物。所述 2-苯基喹喔啉衍生物已被确定为有丝分裂驱动蛋白 MPP1 的特异性抑制剂，可用于治疗癌症和增殖性疾病，包括肿瘤生长和转移。
• [EN] 2-PHENYLQUINOXALINES AS INHIBITORS FOR MPP1<br/>[FR] 2-PHENYLQUINOXALINES COMME INHIBITEURS DE MPP1
  申请人：HAFTEN E V MAX PLANCK GES ZUR

  公开号：WO2006079478A1

  公开（公告）日：2006-08-03

  [EN] The present invention relates to 2-phenylquinoxaline derivatives as well as pharmaceutical compositions containing at least one of these 2-phenylquinoxaline derivatives together with pharmaceutically acceptable carrier, excipient and/or diluents. Said 2-phenylquinoxaline derivatives have been identified as specific inhibitors of the mitotic kinesin MPP1, and are useful for the treatment of cancers and proliferative diseases including tumor growth and metastases.
  [FR] L'invention concerne des dérivés de 2-phénylquinoxaline et des compositions pharmaceutiques contenant au moins un des dérivés de 2-phénylquinoxaline ainsi qu'un support, un excipient et/ou des diluants pharmaceutiquement acceptables. Les dérivés de 2-phénylquinoxaline ont été identifiés comme inhibiteurs spécifiques de la protéine MPPI de la famille des kinésines mitotiques, et sont utiles dans le traitement de cancers et de maladies prolifératives, y compris la croissance tumorale et les métastases.