N-(3-cyclopropyl-1H-pyrazol-5-yl)acetamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(3-cyclopropyl-1H-pyrazol-5-yl)acetamide
• 英文别名: N-(5-cyclopropyl-1H-pyrazol-3-yl)acetamide
• 化学式: C₈H₁₁N₃O
• mdl: MFCD00114563
• 分子量: 165.195
• InChiKey: CSYMKKGYWKPGMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS<br/>[FR] DERIVES DE 3(5)-AMINO-PYRAZOLE, LEUR PROCEDE DE FABRICATION ET LEUR EMPLOI COMME AGENTS ANTI-TUMORAUX
  申请人：PHARMACIA & UPJOHN SPA

  公开号：WO2001012189A1

  公开（公告）日：2001-02-22

  Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3-C6 cycloalkyl group optionally substituted by a straight or branched C1-C6 alkyl or arylalkyl group; R1 is a straight or branched C1-C6 alkyl, C2-C4 alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkenyl group, each of which may be optionally further substituted as indicated in the description; or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.

  化合物是由式（I）表示的3-氨基吡唑衍生物，在该式中，R是C3-C6环烷基，可以选择性地被直链或支链的C1-C6烷基或芳基烷基取代；R1是直链或支链的C1-C6烷基，C2-C4烯基，环烷基，环烯基，杂环烷基，芳基，芳基烷基，芳基羰基，芳氧基烷基或芳基烯基基团，每个基团可以选择性地进一步按照说明中所示取代；或其药学上可接受的盐。这些化合物可用于治疗癌症、细胞增殖性疾病、阿尔茨海默病、病毒感染、自身免疫性疾病或神经退行性疾病。
• Fused pyrimidines as antagonists of the corticotropin releasing factor (crf)
  申请人：——

  公开号：US20040176400A1

  公开（公告）日：2004-09-09

  The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof wherein the variables are as defined in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF). 1

  本发明提供了公式（I）的化合物，包括立体异构体、前药和其药学上可接受的盐或溶剂，其中变量如描述中所定义，以及其制备过程、含有它们的制药组合物以及它们在治疗由促肾上腺皮质激素释放因子（CRF）介导的疾病方面的用途。
• 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1202733A1

  公开（公告）日：2002-05-08
• EP1202733A4
  申请人：——

  公开号：EP1202733A4

  公开（公告）日：2003-05-14
• FUSED PYRIMIDINES AS ANTAGONISTS OF THE CORTICOTROPIN RELEASING FACTOR (CRF)
  申请人：GLAXO GROUP LIMITED

  公开号：EP1383747A1

  公开（公告）日：2004-01-28