6-乙基蝶啶-2,4-二胺 | 192587-16-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 6-乙基蝶啶-2,4-二胺
• 中文别名: 二环[2.2.1]庚烷-2-亚胺,1,7,7-三甲基-,(1R,4R)-
• 英文名称: 6-Ethylpteridine-2,4-diamine
• CAS: 192587-16-9
• 化学式: C₈H₁₀N₆
• 分子量: 190.208
• InChiKey: CMKRFOVMCPRUGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-hydroxyimino-2-butanone 、 2,4,5,6-四氨基嘧啶盐酸盐 以 甲醇 为溶剂， 反应 2.0h， 以76%的产率得到6-乙基蝶啶-2,4-二胺
  参考文献：
  名称：

  一种合成2,6-二取代的4-氨基蝶啶的通用的区域选择性新方法

  摘要：

  描述了一种制备2，6-二取代的4-氨基蝶啶的新的合成方法。在MeOH中用α-酮醛肟处理2-取代的4,5,6-三氨基嘧啶，可以进行区域选择性的一步反应，高产率地生成2,6-二取代的4-氨基哌啶。

  DOI：

  10.1016/s0040-4039(97)01619-5

文献信息

• Pyridine- and Pyrimidinecarboxamides as CXCR2 Modulators
  申请人：Maeda Dean Y.

  公开号：US20100210593A1

  公开（公告）日：2010-08-19

  There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.

  披露了作为药物剂的吡啶和嘧啶羧酰胺化合物，合成过程以及包括吡啶和嘧啶羧酰胺化合物的药物组合物。更具体地，披露了一类CXCR2抑制剂化合物，可用于治疗各种炎症和肿瘤性疾病。
• Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
  申请人：Bockovich Nicholas

  公开号：US20100004207A1

  公开（公告）日：2010-01-07

  The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

  本发明涉及新型细胞周期依赖性激酶抑制剂（CDKs），特别是作为CDK/cyclin复合物的抑制剂，但不仅限于此。如本文所述，本发明的抑制剂能够抑制细胞周期机制，因此可能有助于调节细胞周期进程，最终控制细胞生长和分化。这样的化合物对于治疗与过度细胞增殖有关的疾病的患者是有用的。
• Vasculostatic agents and methods of use thereof
  申请人：Wrasidlo Wolfgang

  公开号：US20070208019A1

  公开（公告）日：2007-09-06

  Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

  本发明提供了用于治疗与血管稳态受损有关的疾病的方法和组合物。本发明的方法和组合物可用于治疗各种疾病，例如中风、心肌梗死、癌症、缺血/再灌注损伤、自身免疫疾病，如类风湿性关节炎、眼部疾病，如视网膜病变或黄斑退化或其他玻璃体视网膜疾病、炎症性疾病、血管渗漏综合征、水肿、移植排斥、成人/急性呼吸窘迫综合征（ARDS）等等。
• VASCULOSTATIC AGENTS AND METHODS OF USE THEREOF
  申请人：Wrasidlo Wolfgang

  公开号：US20100278811A1

  公开（公告）日：2010-11-04

  Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

  本发明提供了用于治疗与血管稳态受损相关的疾病的组合物和方法。本发明的方法和组合物可用于治疗各种疾病，例如中风、心肌梗塞、癌症、缺血/再灌注损伤、自身免疫疾病，如类风湿性关节炎、眼部疾病，如视网膜病变或黄斑变性或其他玻璃体视网膜疾病、炎症性疾病、血管渗漏综合症、水肿、移植排斥、成人/急性呼吸窘迫综合症（ARDS）等。
• PYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS
  申请人：SYNTRIX BIOSYSTEMS, INC.

  公开号：US20140206647A1

  公开（公告）日：2014-07-24

  There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.

  本发明公开了吡啶和嘧啶羧酰胺化合物，可用作药物治疗剂，合成过程和包括吡啶和嘧啶羧酰胺化合物的制药组合物。更具体地，本发明公开了一类CXCR2抑制剂化合物，可用于治疗各种炎症和肿瘤性疾病。